Schering Corporation

Thomas A Sloboth

Robert A Goodnow

Floyd J Shade

Donald J Kaye

Viable cells of an avirulent self-clearing strain of B. bronchiseptica are administered as an intra-respiratory vaccine. An aqueous suspension of the cells is applied to the respiratory mucosa immediately after incorporating a non-inhibitory amount of a wetting agent promoting the mucosal implantation of the cells. Effective immunization can thereby be obtained against diseases such as kennel cough in dogs and atrophic rhinitis in swine even through the strain of B. bronchiseptica is so highly attenuated that it is self-clearing from the respiratory mucosa.

Method of vaccination for prevention of Bordetella bronchiseptica

Nasal nozzle

Method and means for vaccinating a mammal using a convex nozzle with an elongated tip. The mammal's alar fold is pushed aside by the tip so that vaccine is deposited behind the alar fold. Vaccine is then dispensed through the nozzle.

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Omaha, NE, United States of America

Thomas A Sloboth