University of Washington

Acorda Therapeutics, Inc.

The J. David Gladstone Institutes, a Testamentary Trust Established Under the Will of J. David Gladstone

The J. David Gladstone Institutes, a Teatamentary Trust Established Under the Will of J. David. Gladstone

Thomas A Reh

Sheng Ding

Paul Nakamura

Ryo Kubota

Eric J Seibel

Mark Andrew Marchionni

Nagesh K Mahanthappa

David I Gwynne

Olivia Bermingham-McDonogh

Deepak Lamba

Blake Miller

Andrew J Fischer

Olivia M Bermingham-McDonogh

Kathryn L McCabe

Toshinori Hayashi

Methods for decreasing rod gene expression in a retina, methods for decreasing the protein products expressed by rod genes in a retina, methods for treating a disease or condition treatable by decreasing rod gene expression or their protein products in a retina, and methods for treating a retinal disease in a subject.

Methods for treatment of retinal disease by photoreceptor gene expression modulation

The present invention provides reagents and methods for RNA transfection and protein expression.

Compositions and methods for transfection of RNA and controlled stabilization of transfected RNA

Methods are provided for the in vitro differentiation of human retinal progenitor cells from embryonic stem cells.

Method of generating human retinal progenitors from embryonic stem cells

A cell culture system related to extended in vitro culture of mature neuronal cells and methods for preparing the cell culture system are provided. In a preferred embodiment the invention provides a cell culture system comprising a mixture of mature neuronal retinal cells and cells isolated from a ciliary body. Methods for identifying bioactive agents that alter neurodegeneration of neuronal retinal cells are also provided.

Methods and systems for extended in vitro culture of neuronal cells

In one aspect, the invention provides vision prosthesis systems. Exemplary vision prosthesis systems of the invention comprise a light energy generator operably connected to a wearable head piece comprising a device for directing light energy produced by the light energy generator onto a mammalian retina, wherein the light energy generator is tuned to emit light energy of sufficient power to modulate neural activity in the retina. In another aspect, the invention provides methods for irradiating neurons in the retina of the mammalian eye by directing light energy produced by a light energy generator onto a mammalian retina. The methods of the invention may be used to directly modulate the activity of retinal neurons or to introduce molecules into retinal cells.

Scanning laser device and methods of use

In general, the present invention provides methods for promoting the function of retinal cells using neuregulins. A novel aspect of the invention involves the use of neuregulins as growth factors tp promote survival of retinal cells. Treating of the retinal cells to provide these effects may be achieved by contacting retinal cells with a polypeptide described herein. The treatments may be provided to slow or halt net cell loss or to increase the amount or quality of retinal tissue present in the vertebrate.

Methods of treating disorders of the eye

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Seattle, WA, United States of America

Thomas A Reh