Leland Stanford Junior University

The United States Government As Represented by the Department of Veterans Affairs

Thomas A Rando

Anton Wyss-Coray

Saul A Villeda

Markus Britschgi

Marco Quarta

Kaspar Rufibach

Michael J Conboy

Hiu Tung Cheung

Irina M Conboy

Compositions and methods are provided for induction and maintenance of quiescence of stem cells.

Methods and compositions to maintain stem cell quiescence

Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include modulating CCR3, e.g., by modulating eotaxin-1/CCR3 interaction, in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.

Method of treating aging-associated cognitive impairment by reducing CCR3

Method of reducing the effects of aging-associated impairment of neurogenesis comprising modulating c-c chemokine receptor type 3 (CCR3)

Methods of treating cognitive symptoms of an aging-associated impairment by modulating C-C chemokine receptor type 3 (CCR3)

Compositions and methods are provided for altering the activation of quiescent stem cells by modulating activity of the microRNA miR-489.

Activation of quiescent stem cells

The regenerative potential of aged stem cells is enhanced by activation of the Notch signaling pathway and/or inhibition of TGF-&#x3b2; signaling pathway. Stem cells in aged tissues are capable of proliferation and tissue regeneration, but in their native setting are not provided with the appropriate signals to do so. By administering tissue regenerating agents, organ stem/progenitor cells are provided with the appropriate signals to regenerate the corresponding differentiated tissues.

Methods and compositions for regeneration of aged skeletal muscle tissues

Growing community of inventors

Stanford, CA, United States of America

Thomas A Rando