Northwestern University

Other

Southwest Research Institute

Isis Pharmaceuticals, Inc.

Excaliard Pharmaceuticals, Inc.

Ionis Pharmaceuticals, Inc.

Thomas A Mustoe

Ping Xie

Shengxian Jia

Robert D Galiano

Seok Jong Hong

C Frank Bennett

Nicholas M Dean

Walter H Lewis

Mark Sisco

Zol Kryger

Richard J Stonard

Beatriz Porras-Reyes

XingGou Cheng

Frank C Bennet

Nicolas M Dean

Provided herein are compositions, systems, and methods for treating wounds with the combination of statins and cholesterol to help prevent and reduce scar formation.

Topical treatment of wounds with statins and cholesterol for scar reduction

A method of preparing liposomal statins includes preparing a lipid solution including phosphatidylcholine, cholesterol, vitamin-E and an organic solvent and removing the solvent, forming a lipid cake. The lipid cake may then be hydrated with a first aqueous media. The hydrated cake may be mixed in a mixer and subjected to one or more freeze/thaw cycles and then extruded to form liposomes. A cryo-protective agent may be added to the liposomes and the liposomes may be lyophilized to provide a powder. A statin is added to the organic lipid solution or to the first aqueous media used for hydrating the lipid cake.

Liposomal statin formulation

This invention provides a method for reducing hypertropic scarring resulting from dermal wound healing in a subject in need which comprises administering to the subject an antisense oligonucleotide which inhibits expression of connective tissue growth factor (CTGF) in an amount effective to inhibit expression of CTGF and thereby reduce hypertrophic scarring.

Method for reducing scarring during wound healing using antisense compounds directed to CTGF

A wound healing composition is a pharmaceutical dosage unit form including a wound-healing amount of an aporphinoid alkaloid such as taspine free acid, dissolved in a physiologically tolerable non-aqueous solvent such as dimethylsulfoxide.

Wound-healing composition

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Evanston, IL, United States of America

Thomas A Mustoe