Ibis Biosciences, Inc.

Isis Pharmaceuticals, Inc.

Other

Thomas A Hall

Rangarajan Sampath

David J Ecker

Lawrence B Blyn

Steven A Hofstadler

Richard Holmes Griffey

Stanley T Crooke

Mark W Eshoo

John McNeil

Yun Jiang

Vivek Samant

Jared James Drader

James C Hannis

Neill K White

Raymond Ranken

Kristin Sannes-Lowery

Ray Ranken

Vanessa Harpin

Eric Jean Zbinden

Keith R Guetig

John Lawrence Nightingale

Andrew R Collingwood

Amy L Schink

Feng Li

Kristin Sannes Lowery

Christian Massire

Stephen A Hofstadler

Rachael Kreft

Neil White

Rachael Melton

The present invention compositions, methods and systems to identify, detect, and/or quantify bacterial DNA in the presence of contaminating non-bacterial DNA. In particular, the present invention provides oligonucleotides configured to detect a relatively small amount of bacterial DNA in the presence of an overwhelmingly large amount of contaminating human DNA.

Bioagent detection oligonucleotides

The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.

Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy

The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.

Methods for rapid identification of pathogens in humans and animals

The present invention provides methods for the quantification of an unknown bioagent in a sample by amplification of nucleic acid of the bioagent, and concurrent amplification of a known quantity of a calibration polynucleotide from which are obtained a bioagent identifying amplicon and a calibration amplicon. Upon molecular mass analysis, mass and abundance data are obtained. The identity of the bioagent is then determined from the molecular mass of the bioagent identifying amplicon and the quantity of the identified bioagent in the sample is determined from the abundance data of the bioagent identifying amplicon and the abundance data of the calibration amplicon.

Methods for concurrent identification and quantification of an unknown bioagent

The present invention relates to portable systems and devices, and corresponding methods, for detecting bioagents. In particular, the present invention provides systems, devices, and methods that utilize one or more of a sample preparation component, sample analysis component employing broad range primers, and sample detection component.

Bioagent detection systems, devices, and methods

The present invention provides methods and primer pairs for rapid, high-resolution forensic analysis of DNA and STR-typing by using amplification and mass spectrometry, determining the molecular masses and calculating base compositions of amplification products and comparing the molecular masses with the molecular masses of theoretical amplicons indexed in a database.

Methods for rapid forensic DNA analysis

There is a need for nucleic acid analysis which is both specific and rapid, and in which no nucleic acid sequencing is required. The present invention addresses this need, among others by providing a method of nucleic acid amplification of overlapping sub-segments of a nucleic acid followed by molecular mass measurement of resulting amplification products by mass spectrometry, and determination of the base compositions of the amplification products.

Systems and methods for rapid identification of nucleic acid variants

The present invention provides compositions, kits and methods for rapid identification and quantification of sepsis-causing bacteria by molecular mass and base composition analysis.

Methods for identification of sepsis-causing bacteria

The present invention provides methods for rapid forensic analysis of mitochondrial DNA by amplification of a segment of mitochondrial DNA containing restriction sites, digesting the mitochondrial DNA segments with restriction enzymes, determining the molecular masses of the restriction fragments and comparing the molecular masses with the molecular masses of theoretical restriction digests of known mitochondrial DNA sequences stored in a database.

Methods for rapid forensic analysis of mitochondrial DNA

The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.

Compositions for use in identification of bacteria

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Oceanside, CA, United States of America

Thomas A Hall