Imarx Pharmaceutical Corporation

Other

Bristol-myers Squibb Medical Imaging, Inc.

Imar.sub.x Pharmaceutical Corp.

Ford Global Technolgoies, LLC

Nio Usa, Inc.

Karma Automotive LLC

Thomas A Fritz

Evan C Unger

Terry Onichi Matsunaga

VaradaRajan Ramaswami

Guanli Wu

David W Yellowhair

Edward W Gertz

Jon M Nichols

Henrik Fisker

Sino Johan Van Dyk

Paul Boskovitch

Robert Herb

Kevin Walsh

Calvin Chunliang Lee

Billy Tally

James W Shrode

A driver assistance system may be a vehicle control system configured to perform a driver assistance operation, such as implementing cruise control or performing an automated driving control operation. The control system may be configured to perform a driver assistance operation which includes at least one step which conserves energy stored in at least one battery. The control system may conserve energy by controlling a speed or following distance of a vehicle based on road parameter, such as an uphill grade or downhill grade.

Smart cruise control and ADAS for range extension

A system for controlling a mode of operation of a vehicle having a rechargeable energy storage system (RESS), an engine, and a drive motor coupled to the RESS and the engine, the drive motor selectively powered by at least one of the RESS and the engine includes a controller operable to adjust the vehicle to operate in a plurality of operating modes including a first mode in which the drive motor is powered by the RESS, a second mode in which the drive motor is powered more by the engine than the RESS. When the second mode of operation is selected, controller is configured to operate the engine as necessary to maintain the RESS at or above a predetermined state of charge.

Vehicle operation mode systems and methods

An exhaust system for a hybrid electric vehicle includes an exhaust pipe. The exhaust pipe includes a first channel having a first end coupled to an engine of the vehicle and a second end that splits into a second and third channel. The second and third channels extend outwardly to a first front side and to a second front side of the vehicle.

Front end exhaust system

A multi-positional collapsible seat assembly for a motor vehicle is disclosed. The seat assembly includes a seat bottom having a load surface provided on an underside thereof and a seat back having a load surface provided on the back side thereof. As the seat assembly is collapsed, the seat bottom is pivoted forward and the seat back is pivoted adjacent to the seat bottom such that the load surfaces collectively provide a load floor for receipt of cargo. An armrest assembly is disclosed that facilitates both passenger and cargo transport. A method is also disclosed for collapsing the seat assembly.

Collapsible seat assembly

Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled liposomes having a drug encapsulated therein are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in therapeutic delivery applications are also disclosed.

Therapeutic delivery systems

Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.

Method of preparing gas and gaseous precursor-filled microspheres

Therapeutic delivery systems comprising gaseous precursor-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Therapeutic delivery systems comprising gaseous precursor-filled liposomes having encapsulated therein a contrast agent or drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in therapeutic delivery applications are also disclosed.

Improved methods for providing an image of an internal region of a patient. Embodiments of the invention involve the administration to the patient of a contrast agent which comprises, in an aqueous carrier, a lipid, protein, polymer or surfactant, and a gas. The patient is scanned using ultrasound imaging to obtain a visible image of the region. In embodiments of the invention, the scanning step may comprise applying a first quantity of ultrasound energy to the patient to provide a first image, followed by the application substantially immediately thereafter of a second quantity of ultrasound energy to provide a second image. The first and second images are then processed. The methods are particularly useful for obtaining on-line images of the cardiovascular region which may be employed, for example, to diagnose the presence of diseased tissue in the cardiovascular region of a patient.

Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same

Novel contrast agents which may be used for diagnostic and therapeutic use. The compositions may comprise a lipid, a protein, polymer and/or surfactant, and a gas, in combination with a targeting ligand. In preferred embodiments, the targeting ligand targets coagula, including emboli and/or thrombi, particularly in patients suffering from an arrhythmic disorder. The contrast media can be used in conjunction with diagnostic imaging, such as ultrasound, as well as therapeutic applications, such as therapeutic ultrasound.

Targeted contrast agents for diagnostic and therapeutic use

Targeted gas and gaseous precursor-filled liposomes

Lyophilized lipid compositions, as well as methods for their preparation, are embodied by the present invention. Gas-filled microspheres prepared using the lyophilized lipid composition are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.

Method of preparing fluorinated gas microspheres

Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

Methods for diagnostic imaging by regulating the administration rate of

Methods of and apparatus for preparing gas-filled liposomes are described. Gas-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.

Growing community of inventors

Tucson, AZ, United States of America

Thomas A Fritz