Baxter International Inc.

Baxter Travenol Laboratories, Inc.

Other

Thomas A Fowles

Robert J Weinberg

David A Winchell

Thomas J Progar

Craig A Fuller

Mark A Hoekwater

Brian J Gorman

Glenn L Slater

Charles Eller

William J Schnell

Jeffrey S Nordquist

Richard A Rollins

Richard J Mitchell

Joseph A Bancsi

Terrance J Hebron

Joseph C Wong

Ray W Wood

Haruki Kazama

Kazumasa Maeda

James L Sertic

Brian C Green

Donald A Jess

Charles Jersild

Nick Fotis

Fumiaki Nishimoto

Nicholas Gibbons

William C Corrigan, Jr

Albert Henhapl

Robert J Weinburg

Richard D'Amico

A reconstitution assembly includes: a flexible bag containing a diluent; a drug vial containing a drug; a reconstitution device further comprising: a first sleeve connected to the first container; a second sleeve connected to the second container, the second sleeve being associated with the first sleeve and movable axially with respect thereto from an inactivated position to an activated position; a piercing member positioned in the sleeves, the piercing member providing a fluid pathway between the bag and vial when the sleeves are in the activated position.

Reconstitution assembly, locking device and method for a diluent container

The present invention provides a connector device or reconstitution device () for placing a first container (), such as a liquid container (e.g. flexible container or syringe), in fluid communication with a second container (), such as a drug vial. The connector device () has a first sleeve () having a first end () and a second end (). The first sleeve () has at the first end (), a first attaching member () adapted to attach to the liquid container (). The connector device () also has a second sleeve () having a first end () and a second end (). A second attaching member () is attached on the second end () of the second sleeve () and is adapted to attach to the second container (). The second attaching member () has a sealing member (). A piercing member () projects within the sleeves () for providing a fluid flow path from the first container () to the second container (). The connector device () is movable from the inactivated position to the activated position wherein the second sleeve () moves axially with respect to the first sleeve () and wherein the piercing member places the first container () and the second container () in fluid communication. The connector device () includes structure for preventing premature activation of the connector device ().

Sliding reconstitution device for a diluent container

The present invention provides a reconstitution device () for placing a first container (), such as a liquid container (e.g. flexible container or syringe), in fluid communication with a second container (), such as a drug vial. To this end, there is provided a connector device () for establishing fluid communication between the diluent container () and the drug vial (). The connector device () has a first sleeve member () having a first end () and a second end (). The first sleeve member () has at the first end (), a first attaching member () adapted to attach to the liquid container (). The connector device () also has a second sleeve member () having a first end () and a second end (). The second sleeve member () is movable axially with respect to the first sleeve member () from an inactivated position to an activated position. The second sleeve member () has a protuberance () on an inner surface of the second sleeve member (). A second attaching member () is attached on the second end () of the second sleeve member () and is adapted to attach to the second container (). The second attaching member () has a sealing member (). A piercing member () is positioned in the chamber and projects within the sleeve members () for providing a fluid flow path from the first container () to the second container (). The piercing member () is moveable from a first position in the inactivated position to a second position in the activated position wherein the piercing member () moves past the protuberance (), the protuberance () preventing movement of the piercing member () back to the first position. The device () is movable from the inactivated position to the activated position by a force generally applied to the device outside the liquid container ().

A connector device is disclosed for establishing fluid communication between a diluent container having sidewalls and a drug vial. The connector has a piercing member having a first end and a second end and a central fluid pathway. The piercing member is mounted to the liquid container and has fluid accessing portions hermetically sealed from an outside environment. A vial receiving chamber is associated with the piercing member and is dimensioned to connect to the vial. The vial may be selectively attached to the device without piercing the closure of the vial and without breaching the hermetic seal of the fluid accessing portions of the piercing member. Means are provided for connecting the vial receiving chamber to the liquid container. The device is movable from an inactivated position, where the piercing member is outside the sidewalls and no fluid flows between the liquid container and the drug vial, to an activated position, where fluid flows through the fluid pathway between the liquid container and the drug vial. The device is movable from the inactivated position to the activated position by a force applied to the device outside the liquid container.

Vial connecting device for a sliding reconstitution device for a diluent container

The present invention provides a connector device for establishing fluid communication between a first container and a second container. The device has a first sleeve member having a first and a second end, the first sleeve member having at the first end a first attaching member adapted to attach to the first container. The device further has a second sleeve member having a first end and a second end, the second sleeve member being associated with the first sleeve member and movable with respect thereto from an inactivated position to an activated position, the second sleeve member having at the second end a second attaching member adapted to attach the second sleeve member to the second container. First and second piercing members project from one of the first and second sleeve members for providing a fluid flow path from the first container to the second container, and the first and second piercing members are independently hermetically sealed.

Sliding reconstitution device with seal

The present invention provides a method of connecting a reconstitution device to a drug container having a top and a closure. The method includes the steps of:

Vial connecting device for a sliding reconstitution device for a diluent

The present invention provides a connector device for establishing fluid communication between a first container and a second container. The device has a first sleeve member having a first and a second end, the first sleeve member having at the first end a first attaching member adapted to attach to the first container. The device further has a second sleeve member having a first end and a second end, the second sleeve member being associated with the first sleeve member and movable with respect thereto from an inactivated position to an activated position, the second sleeve member having at the second end a second attaching member adapted to attach the second sleeve member to the second container. First and second piercing members project from one of the first and second sleeve members for providing a fluid flow path from the first container to the second container, and the first and second piercing members are independently hermetically sealed. A septum seals the second piercing member and has a disk having opposing first and second surfaces. A well portion extends axially from the first surface of the disk and a sheath extends axially from the well portion. An annular ridge extends from the second surface of the disk and has a flared distal end dimensioned to form a fluid tight seal with the closure of the container. The septum further has a vertical peripheral edge and an inclined peripheral edge. A gusset is located on the second attaching member and has a vertical gusset surface and an inclined gusset surface. The vertical gusset surface confronts the vertical peripheral edge, and the inclined gusset surface confronts the inclined peripheral edge.

Septum for a sliding reconstitution device with seal

The present invention provides a connector device for establishing fluid communication between a first container and a second container. The device has a first sleeve member having a first end and a second end, the first sleeve member having at the first end a first attaching member adapted to attach to the first container; and a second sleeve member having a first end and a second end, the second sleeve member being associated with the first sleeve member and movable axially with respect thereto from an inactivated position to an activated position. A second attaching member is provided on the second end of the second sleeve and adapted to fixedly attach the second sleeve member to the second container. First and second piercing members are also provided projecting from one of the first and second sleeve members for providing a fluid flow path from the first container to the second container.

Vial connecting device for a sliding reconstitution device with seal

Growing community of inventors

McHenry, IL, United States of America

Thomas A Fowles