The Dow Chemical Company

Merrell Dow Pharmaceuticals

Merrell Pharmaceuticals, Inc.

Virginia Polytechnic Institute and State University

Thomas A Chamberlin

Michael J Mullins

Donald A Tomalia

Alan D Cardin

Michael J Fazio

William A Fordyce

Norman L Madison

Sonia W Bangs

Robert E Hefner, Jr

James C Stevens

William Jack Kruper, Jr

Maurice J Marks

James E McGrath

Stephen E Bales

Hendrik E Tuinstra

Anthony P Haag

David A Carr

Rafael Galvan

Daniel M Knauss

L Wayne White

Gerald L Kochanny, Jr

The narrow poly- or mono-dispersed oligomers of the present invention are polyureas, polycarbonates, polyesters or polyamides having a recurring unit of from 3 to 50. These oligomers are water-soluble, preferably have a rigid backbone, have recurring units coupled by carbonyl linking moieties which have anionic groups, display predominantly linear geometry such that regular spacing between anionic groups exists in an aqueous medium, and are pharmaceutically-acceptable. The narrow poly- or mono-dispersed oligomers are useful for the treatment and/or diagnosis of AIDS and/or ARC or HSV.

Narrow poly-and-mono-dispersed anionic oligomers, and their uses,

Narrow poly- and mono-dispersed anionic oligomers

A process which includes the step of heating a compound of Formula (I): ##STR1## wherein R.sup.1 is a hydroxyphenyl group or a group of Formula (II): ##STR2## and R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are independently in each occurrence H or a C.sub.1-10 alkyl group; to a temperature in the range of from 100.degree. C. to 400.degree. C. under reaction conditions sufficient to form one or more 4,4'-dihydroxy-alpha-substituted stilbenes.

Process for the preparation and purification of

The narrow poly- or mono-dispersed oligomers of the present invention are polyureas, polycarbonates, polyesters or polyamides having a recurring unit of from 3 to 50. These oligomers are water-soluble, preferably have a rigid backbone, have recurring units coupled by carbonyl linking moities which have anionic groups, display predominantly linear geometry such that regular spacing between anionic groups exists in an aqueous medium, and are pharmaceutically-acceptable. The narrow poly- or mono-dispersed oligomers are useful for the treatment and/or diagnosis of AIDS and/or ARC or HSV.

Narrow poly- and mono-dispersed anoinic oligomers, and their uses,

Narrow poly- and mono-dispersed anionic oligomers, and their uses,

There are disclosed carbonate polymers having ethenyl aryl moieties. Such carbonate polymers are prepared from one or more multi-hydric compounds and have an average degree of polymerization of at least about 1 based on multi-hydric compound. These polymers, including blends thereof, can be easily processed and shaped into various forms and structures according to the known techniques. During or subsequent to the processing, the polymers can be crosslinked, by exposure to heat or radiation, for example, to provide crosslinked polymer compositions. These compositions have a good combination of properties, including for example, processability into shaped articles having unexpectedly good combinations of toughness, solvent resistance, ignition resistance, modulus and resistance to thermal linear expansion.

Carbonate polymers containing ethenyl aryl moieties

Diaryl carbonates are prepared by the catalyzed reaction of an aryl hydroxide with a carbonyl halide in the liquid phase at a temperature from greater than 100.degree. to less than 150.degree. C.

Diaryl carbonate process

A proces for regenerating a spent catalyst comprising uranium and a poly-substituted cyclopentadienyl ligand comprising contacting the deactivated catalyst with hydrogen under reaction conditions. The regenerated catalyst is active in the selective dimerization of propylene to 4-methyl-1-pentene.

Regeneration of an organouranium catalyst

Method and apparatus for determining various molecular weight distribution parameters by concurrent measurement of hydrodynamic volume, specific viscosity and mass. Essentially concurrent viscosity and mass detectors are described, as are improved methods for viscosity detection, which together provide substantially improved results.

Method and apparatus for determining polymer molecular weight

A process for the nitration of a tetraarylporphyrin compound such as tetraphenylporphyrin by use of a nitrating agent in a suitable solvent in the presence of an amount of sulfuric acid that is less than equimolar relative to the amount of nitrating agent.

Regiospecific aryl nitration of meso-substituted tetraarylporphyrins

Compounds represented by the formula: ##STR1## and addition polymers thereof where m is an integer from 2 to about 10, X-- is chlorine, hydroxy, carboxy or:

Vinyl substituted cyclic polyethers and addition polymers thereof

Compounds represented by the formula ##STR1## and addition polymers thereof where m is an integer from 2 to about 10, X- is chlorine, hydroxy, carboxy or

Compounds represented by the formula ##STR1## and addition polymers thereof where m is an integer from 2 to about 10, x--is chlorine, hydroxy, carboxy or

Metal salt complexes of vinyl-substituted cyclic polyether addition

Novel solid complexes of 2-oxazoline and 2-oxazine polymers and halogens, interhalogens or pseudo-halogens are prepared by contacting a poly-2-oxazoline or poly-2-oxazine whose backbone comprises a plurality of ring-opened units of an oxazoline or oxazine monomer of the general formula ##STR1## wherein R and R.sub.1 -R.sub.4 are each independently hydrogen, alkyl, aralkyl, phenyl or inertly-substituted phenyl and n is zero or one with a halogen, interhalogen or pseudo-halogen. The complexes are soluble in a variety of conventional solvents (e.g., water, methylene chloride, acetonitrile, methanol, tetrahydrofuran and isopropanol).

Novel complexes of polyoxazolines or polyoxazines and halogens,

Phenolics are complexed with acylated polyamines to form materials which are essentially water-insoluble. This phenomenon makes acylated polyamines particularly useful in removing phenolics from aqueous waste streams.

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Midland, MI, United States of America

Thomas A Chamberlin