Map Pharmaceuticals, Inc.

Xoc Pharmaceuticals, Inc.

Ai Therapeutics, Inc.

Sheffield Pharmaceuticals, Inc.

Map Pharceuticals, Inc.

Al Therapeutics, Inc.

Systemic Pulmonary Development, Ltd.

Orphai Therapeutics Inc.

Thomas A Armer

Robert Owen Cook

Scott Borland

Miguel Guzman

Jian Zhang

Geoff McKinley

Jonathan Marc Rothberg

Henri Lichenstein

Lawrence S Melvin, Jr

Ármin Szabolcs

János Gerencser

Stephen B Shrewsbury

Nabih N Ramadan

Richard Matthew Pavkov

Nahed Mohsen Mohsen

Bryce Burwick Evans

Jonathan M Rothberg

Atul M Sudhalkar

Lawrence S Melvin

Dejian Xie

Sergey Alexandrovich Kosarev

Donald J Kellerman

Nahed M Mohsen

The present invention relates to methods and compositions for treating lymphangioleiomyomatosis in a human subject in need of such treatment. The methods comprise administering to the subject via inhalation an aerosol composition comprising rapamycin or a prodrug or derivative (including analog) thereof.

Rapamycin for the treatment of lymphangioleiomyomatosis

The present invention relates to methods and compositions for anti-aging therapy and for the treatment and prophylaxis of age-related diseases and disorders in a human subject in need of such therapy or treatment, the methods comprising the pulmonary administration to the subject, preferably via inhalation, of composition comprising rapamycin, or a prodrug or derivative thereof.

Inhalable rapamycin formulation for treating age-related conditions

The present invention relates to methods and compositions for the treatment and prophylaxis of pulmonary arterial hypertension (PAH) in a human subject in need of such treatment, the methods comprising the pulmonary administration to the subject, preferably via inhalation of a composition comprising rapamycin or a prodrug or derivative thereof.

Inhalable rapamycin formulation for the treatment of pulmonary hypertension

The present invention provides novel neuromodulatory compounds and compositions thereof. The invention also relates to methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; as well as intermediates for the preparation compounds.

Polycyclic compounds and uses thereof

Provided herein are ergoline compounds and pharmaceutical compositions thereof. In some embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and pharmaceutical compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT, 5-HTand 5-HTreceptors without agonizing the 5-HTreceptor using the compounds and pharmaceutical compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing the 5-HTadrenergic alphaand/or the alphareceptors using the compounds and pharmaceutical compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing the D2 and D3 receptor using the compounds and pharmaceutical compositions disclosed herein.

Ergoline compounds and uses thereof

Pharmaceutical compositions containing dihydroergotamine (DHE) and methods in which DHE is administered to patients for treatment of migraine without side effects or adverse effects are disclosed. Methods for rapid treatment of migraine with DHE are disclosed comprising: dampening the peak plasma concentration (C) and slightly delaying the peak such as to avoid activating the dopaminergic and adrenergic receptors, while achieving sufficient active binding to the serotonin receptors to provide relief from migraine symptoms within a timeframe that permits rapid resolution of migraine symptoms. Inhaler devices suitable for the methods are disclosed. Kits for practicing the methods of invention are disclosed.

Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile

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Cupertino, CA, United States of America

Thomas A Armer