Deciphera Pharmaceuticals, LLC

Thiwanka Samarakoon

Daniel L Flynn

Michael D Kaufman

Timothy Malcolm Caldwell

Lakshminarayana Vogeti

William C Patt

YuMi Ahn

Karen M Yates

Gary E L Brandt

Hanumaiah Telikepalli

Described are compounds of Formula I which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-FMS, c-KIT, or PDGFR kinases.

N-acyl-N'-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities

Described are compounds of Formula 1 which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-FMS, c-KIT, or PDGFR kinases.

1,2,4-triazol-5-ones and analogs exhibiting anti-cancer and anti-proliferative activities

Imidazolidinones and analogs exhibiting anti-cancer and anti-proliferative activities

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Quincy, MA, United States of America

Thiwanka Samarakoon