Rigel Pharmaceuticals, Incorporated

Thilo J Heckrodt

Rajinder Paul Singh

Sacha Holland

Hui Li

Yan Chen

Rose Yen

Jing Zhang

Pingyu Ding

Vanessa Taylor

Kin Tso

Dane A Goff

Darren J McMurtrie

Joane Litvak

Jiaxin Yu

Ryan Kelley

Esteban Masuda

Matthew Duncton

Rao Kolluri

Jack Maung

Salvador Alvarez

Dane Goff

Donald G Payan

Simon Shaw

Catherine Sylvain

Pingu Ding

Sambaiah Thota

Sambaiah Thhota

Darren Mcmurtrie

Darren John Mcmurtrie

Rajinder Singh

Disclosed embodiments concern interleukin receptor associated kinases (IRAK) inhibitors, such as oxazole compounds, and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.

IRAK inhibitors and method for making and using

Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitors and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.

Amide compounds and method for making and using

Pyrazole compounds and methods for making and using the compounds

Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful. Also disclosed are methods of making the compounds.

Compositions and methods for inhibition of the JAK pathway

This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Protein kinase C inhibitors and uses thereof

Pyrazole compounds and method for making and using the compounds

Growing community of inventors

South San Francisco, CA, United States of America

Thilo J Heckrodt