Xenon Pharmaceuticals Inc.

Genentech, Inc.

Thilo Focken

Christoph Martin Dehnhardt

Michael Edward Grimwood

Sultan Chowdhury

Alla Yurevna Zenova

Michael Scott Wilson

Jean-Christophe Andrez

Qi Jia

Ivan William Hemeon

Shaoyi Sun

Brian Salvatore Safina

Kristen Nicole Burford

Daniel P Sutherlin

Paul Robert Bichler

Daniel Fred Ortwine

Philippe Bergeron

Shannon Marie Decker

Verner Alexander Lofstrand

Abid Hasan

Syed Abid Hasan

Robert Joseph Devita

Wei Gong

James Philip Johnson, Jr

Tao Sheng

James Roy Empfield

Charles Jay Cohen

Jun M Li

Steven Sigmund Wesolowski

Steven McKerrall

Zhiguo Liu

Jiuxiang Zhu

Andrew D White

Chien-An Chen

Tao Wang

Zaihui Zhang

David Earl Bogucki

Shifeng Liu

Kwong Wah Lai

Julia Fonarev

Renata Marcella Oballa

Navjot Chahal

Teresa Phuongtram Nguyen

James Philip Johnson

Jun Li

Jr Johnson James Philip

This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.

Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents

Benzenesulfonamide compounds and their use as therapeutic agents

This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.

The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R, R, subscript n, ring A, X, L, subscript m, X, ring B, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Substituted benzamides and methods of use thereof

Benzenesulfonamide compouds and their use as therapeutic agents

The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables R, R, subscript n, subscript q, ring A, X, L, subscript m, X, R, R, R, R, R, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Therapeutic compounds and methods of use thereof

The invention provides a compound of formula: or a salt thereof, wherein the variables R, n, ring A, ring B, R, R, R, R, R, R, R, R, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

The invention provides compounds having the general formula I: (i) and pharmaceutically acceptable salts thereof, wherein the variables R, R, subscript n, ring A, X, L, subscript m, X, ring B, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

This invention is directed to heteroaryl-substituted sulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.

Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors

This invention is directed to methods of preparing benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.

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Burnaby, Canada

Thilo Focken