Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Centre National De La Recherche Scientifique

Commissariat a L'energie Atomique

Cis Bio International

Aryballe

Institut National De La Sante Et De La Recherche Medicale

Université Grenoble Alpes

Université Paris—sud

Elicityl

Prestodiag

Genoptics

Aryballe Technologies

Université Joseph Fourier

Commissariat a L'energie Atomique Et Aux Energies Alternatives

Thierry Livache

Robert Teoule

Patrice Caillat

Olivier Dellea

Cyril Herrier

Yanxia Hou-Broutin

Tristan Rousselle

Andr&eacute; Roget

Thibaut Mercey

Andre Roget

Christelle Barthet

Arnaud Buhot

Yoann Roupioz

Brigitte Fouque

Sophie Brenet

Pierre Labeye

Mathieu Dupoy

Yves Levy

Maryse Fournier

Didier Molko

Philippe Peltie

Sylvie Sauvaigo

Bernard Maillere

David Bonnaffe

Gerard Bidan

Hugues Lortat-Jacob

François-Loïc Cosset

Patrice Marche

Alain Heyraud

Silvère Bonnet

Stéphane Havet

Benoît Darblade

Bruno Lina

Olivier Ferraris

Ho Hong Hai Vo

Roberto Calemczuk

David Carrara

Loic Leroy

Francois-Xavier Gallat

Thierry Vernet

Judit Szecsi

Julia Bartoli

Rabia Sadir

Bruno Corso

Nathalie Lassalle

Frédéric Lesbre

Félix Piat

G&eacute;rard Bidan

Didier Gasparutto

Anne-Marie Duplaa

Sami Slimani

Romain Dubreuil

Karim Vindas

Loïc Laplatine

Elodie Engel

Sarah Milgram

André Roget

Claire Durmort

Cristina-Cassiana Andrei

Christophe Moreau

Loïc Leroy

Myriam Cubizolles

Sihem Bouguelia

A detection system for an electronic nose which allows a physicochemical classification of odors, that is to say a classification as a function of the physicochemical properties of the volatile compounds, or odorous molecules, making up these odors. This detection system comprises sensors with cross-reactivity with respect to volatile compounds, each sensor comprising a sensitive part functionalized by a receptor comprising a sequence formed by the repetition of an α-amino acid. The α-amino acid of the receptor of a sensor of a first series of sensors is hydrophilic, while the α-amino acid of the receptor of another sensor of the first series is hydrophobic, and the α-amino acids of the receptors of two sensors of a second series of sensors have isoelectric points which differ from one another by at least one pH unit.

Detection system for an electronic nose allowing a physicochemical classification of odours and electronic nose comprising such a system

A method determines a potential poisoning of a sensor of an electronic nose by a volatile compound following an exposure of the sensor to a gaseous sample including at least this volatile compound. If there is poisoning, the method determines whether the sensor is still functional such that the sensor is still capable of carrying out one or a plurality of reliable measurements, or on the contrary, whether the sensor is saturated and must no longer be used. The method may be used with any type of electronic nose.

Method for determining a potential poisoning of a sensor of an electronic nose by a volatile compound

A photonic integrated circuit for an interferometric sensor includes a first waveguide called sensitive arm wherein a first portion of the light radiation is propagated, the sensitive arm being exposed to a first ambient medium and to at least one compound to be detected inducing a modification of the local refractive index perceived by the evanescent part of the electromagnetic field of the first portion of the light radiation, and a second waveguide called reference arm wherein a second portion of the light radiation is propagated, an encapsulation layer encapsulating the reference arm, the encapsulation layer being impermeable to the compound or compounds to be detected, so that the reference arm is exposed only to a second ambient medium, substantially of the same nature as the first ambient medium and without the compound to be detected and interferometric sensor comprising a photonic integrated circuit according to the invention.

Photonic integrated circuit with encapsulated reference arm

The invention relates to a detection system for an electronic nose capable of detecting and identifying a set of compounds that can be found in a gaseous sample, the detection system comprises a plurality of cross-reactivity detection sensors (D, D, D, D, D, D, D) for supplying signals representing the presence of one or more compounds of said set in the gaseous sample, and which is particularly characterised in that the detection system further comprises at least one reference sensor (RI) for supplying a signal representing the measurement noise of the detection system. The detection system further relates to an electronic nose comprising such a detection system.

Detection system for an electronic nose and an electronic nose comprising such a system

The present invention relates to a sensor for an electronic tongue or nose for analysing a sample or detecting a target. The sensor comprises a support, on one surface of which a plurality of sensitive areas are located, each sensitive area comprising at least one receptor and being capable of transmitting a measurable signal generated by the interaction of at least one constituent of the sample or one target with at least one receptor. The sensor is characterised in that it comprises at least three sensitive areas that differ from one another in terms of their respective receptor compositions, at least one of the sensitive areas comprising a mixture of at least two different receptors, while the two other sensitive areas each comprise at least one of the two receptors.

Electronic nose or tongue sensors

The invention relates to a method for detecting a local change in refractive index of a dielectric medium located on the surface of an optical sensor, said optical sensor comprising for this purpose a waveguide comprising a region, called the active region, covered with at least one metallic layer in contact with the dielectric medium, said method comprising the following steps:

Method for detecting a local change in refractive index of a dielectric medium located on the surface of an optical sensor

The invention relates to a method for calibrating an electronic nose, said electronic nose comprising a plurality of optical sensors arranged on a surface and capable of being in contact with a gaseous medium of interest, said optical sensors being capable of delivering a signal representative of the local optical index of the gaseous medium of interest when they are excited by photons, the method being characterized in that it comprises the following steps: after having placed the electronic nose in a gaseous medium of interest at the initial pressure (P) and the initial temperature (T): a) sending photons in the direction of the sensors so as to excite said sensors; b) measuring the signal delivered by each of the sensors, this measurement providing as many responses as there are sensors; c) modifying the pressure and/or temperature of the gaseous medium of interest; d) repeating step b); and e) for each sensor, determining a correction factor such as a variation in the signal between steps d) and b) corrected by the correction factor either equal to or substantially equal to a variation in the signal between these same steps for a reference, said reference being provided by a reference sensor or a combination of reference sensors. Such a method allows a physical calibration, that in the present case is relative, to be performed between the different sensors.

Method of calibrating an electronic nose

The present invention relates to a method of analysis comprising the preparation and the analysis of a sample in a flexible container without direct handling of the sample and without reopening the flexible container at the end of the preparation of the sample, and also to a container and a kit that enable the implementation of this method.

Method of microbiological analysis of a sample in a unique container

The present invention relates to a method for real-time measurement of the secretion of at least one compound by at least one individual cell, comprising:

Method for real-time measurement of the individual secretions of a cell

The present invention relates to polysaccharides selected from sulphated arabinogalactans, apiogalacturonans and sulphated heteroglycans intended to be used as a drug for the preventive or curative treatment of an influenza virus, as well as to the pharmaceutical compositions including, in particular in combination with at least one pharmaceutically acceptable carrier:

Sulphated arabinogalactans, apiogalacturonans and sulphated heteroglycans for treating diseases caused by the influenza virus

The invention relates to a device for receiving a fluid sample, which is designed such as to form an electrode, such as a counter electrode or a working electrode, in an electrochemical cell. The inventive device comprises an end part having at least one cavity which opens to the exterior via an opening and which is equipped with a base. The invention is characterized in that the aforementioned end part comprises a first electrically-insulating hydrophobic zone which is adjacent to the cavity opening and a second electrically-conducting hydrophilic zone which is adjacent to the first zone and which at least partially covers the base of the cavity, such that, when the end part is immersed in the fluid and then removed therefrom, the cavity retains part of the fluid by means of capillary action.

Device for receiving a fluid sample and applications thereof

The aim of the present invention is to provide a method for attaching a protein to a conductive polymer, that can be used in particular for producing a sensor or a multisensor, for example a biochip. This aim, and also others, are achieved, in accordance with the invention, by means of a method for attaching a protein to a pyrrole polymer, comprising the following steps:

Method for fixing a protein on a pyrrole-based polymer and use thereof for making a sensor

A method for fabricating matrices of addressed ligands on a carrier. In the method, an element is used such as a reservoir filled with ligand and containing an electrode to deposit and electrochemically fix the ligand to the conductive carrier. The ligand may be an oligonucleotide or a peptide, and fixing may be obtained by electrocopolymerisation of this oligonucleotide or peptide carrying a pyrrole group at 5' with pyrrole.

Method for producing addressed ligands matrixes on a support

A method and device for testing an electronic chip ( ) having on the surface a plurality of addressable electrically conductive sensitive elements ( ) in which the sensitive elements on the chip are put in contact with a conductive solution ( ), one or more sensitive elements ( ) are addressed selectively in order to apply to each sensitive element addressed an electrical test signal referred to as an input signal, and a signal, referred to as the output signal, on an electrode ( ) also in contact with the conductive solution, is measured.

Device and method for testing sensitive elements on an electronic chip

Chip-based analysis device comprising electrodes with localized heating

Growing community of inventors

Jarrie, France

Thierry Livache