Actelion Pharmaceuticals Ltd

Idorsia Pharmaceuticals Ltd

Thierry Kimmerlin

Kurt Hilpert

Francis Hubler

Dorte Renneberg

Simon Stamm

Christoph Boss

Heinz Fretz

Eva Caroff

Emmanuel Meyer

Julien Pothier

Philippe Guerry

Francois Lehembre

Anja Valdenaire

Hamed Aissaoui

Daniel Bur

Markus Gude

Sylvaine Cren

Romain Siegrist

Hervé Siendt

Mark Murphy

Thomas Pfeifer

Claire-Lise Ciana

Marcel Keller

Rémy Castro

Naomi Tidten-Luksch

Carina Lotz-Jenne

Herve Siendt

Remy Castro

The present invention relates to compounds of Formula (I) inhibiting indoleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3-dioxygenase (TDO) enzymes. Further, their synthesis and their use as medicaments in inter alia cancer is disclosed. 

Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase

The invention relates to compounds of Formula (I) wherein R, R, R, Rand Rare as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor. 

8-(piperazin-1-yl)-1,2,3,4-tetrahydro-isoquinoline derivatives

The present invention relates to derivatives of formula (I) wherein (R), R, R, R, R, R, L, L, X, Y and Arare as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.

CXCR7 receptor modulators

The invention relates to indole carboxamide derivatives of formula (I), wherein R, R, R, R, Rand Rare as defined in the description, their preparation and their use as pharmaceutically active compounds.

Indole carboxamide derivatives as P2X7 receptor antagonist

The invention relates to novel acrylamide derivatives of the formula I 

Acrylamide derivatives as antimalarial agents

The present invention relates to 1-[m-carboxamido(hetero)aryl-methyl]-heterocycyl-carboxamide compounds of formula (I) 

1-[m-carboxamido(hetero)aryl-methyl]-heterocyclyl-carboxamide derivatives

The invention relates to heterocyclic amide derivatives of formula (I), 

Heterocyclic amide derivatives as P2X7 receptor antagonists

The invention relates to compounds of Formula (I), wherein ring A, X, (R), R, R, R, R, R, n, and p are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor.

4-(benzoimidazol-2-yl)-thiazole compounds and related aza derivatives

The invention relates to heterocyclic amide derivatives of formula (I), wherein R, R, R, R, R, X, Y and n are as defined in the description, their preparation and their use as pharmaceutically active compounds. 

Growing community of inventors

Allschwil, Switzerland

Thierry Kimmerlin