Centre National De La Recherche Scientifique

Ecole Polytechnique

Saint-gobain Glass France

Gen-probe, Inc.

Essilor International (compagnie Generale D'optique)

Genewave

Genewave Sas

Essilor International

Rhodia Electronics & Catalysis

Thierry Gacoin

Jean-Paul Cano

Claudine Biver

Jean-Yves Chane-Ching

Jean-Pierre Boilot

Claude Weisbuch

Valérie Buissette

Henri Benisty

Christof Schafauer

Khalid Lahlil

John Biteau

Sandrine Duluard

Antigoni Alexandrou

Arnaud Huignard

Mamonjy Cadet

Sophie Besson

Thierry Le Mercier

Lucio Martinelli

Muriel Matheron

Gabriel Sagarzazu

Mélanie Bedu

Cédric Bouzigues

Pascal Preira

Maximilian Richly

Mauricette Rondet

Sandrine Ithurria

Lethicia Gueneau

Jacques Peretti

Catherine Jacquiod

Laurianne Vagharchakian

Christian Ricolleau

Jean-Marc Berquier

Mouna Abdesselem

Alistair Rowe

Clarisse Durand

Rabei Mohammedi

Jong Wook Kim

Joëlle Corde

Tapajyoti Das Gupta

Lorraine Raboin

Sandrine Perruchas

A biochip device comprising a substrate constituted by at least one plate of material forming a multimode planar waveguide and carrying chromophore elements suitable for emitting fluorescence in response to excitation by guided waves having an evanescent portion, the device being characterized in that it includes coupling means for coupling excitation light with the waveguide in the form of guided waves, the coupling means being substantially non-directional.

Biochip method

A process for ultrasensitive in vitro detection and/or quantification of a substance of interest in a sample is performed by detecting the luminescence emission by photoluminescent inorganic nanoparticles. The process includes (i) use of photoluminescent particles comprising a photoluminescent inorganic nanoparticle consisting of a crystalline matrix having at least 10rare-earth ions, and coupled to a targeting agent for the substance to be analyzed, under conditions conducive to their association with the sample substance to be analyzed; (ii) exciting the rare-earth ions of the particles by an illumination device having a power of at least 50 mW and an excitation intensity of at least 1 W/cm; (iii) detecting the luminescence emission by the particles after single-photon absorption; and (iv) determining the presence and/or concentration of the substance by interpreting said luminescence measurement. This process can be used for in vitro diagnostic purposes and as an in vitro diagnostic kit.

Ultra-sensitive detection method using photoluminescent particles

A biochip device includes a waveguide, chromophore elements, a diffusing structure, and a sloping surface. The chromophore elements are disposed on a portion of the waveguide and are configured to emit fluorescence in response to excitation by guided light waves transmitted by the waveguide. The diffusing structure is configured to generate guided light waves in the waveguide when illuminated. The sloping surface is sloped relative to a plane of the waveguide and is configured to direct excitation light into the waveguide, and the sloping surface and the waveguide are configured to deflect the excitation light to the diffusing structure to generate guided light waves within the waveguide. The sloping surface may be a face of a prism attached to or integrated with the waveguide, or the sloping surface may be a bevel formed at an edge of the waveguide.

Biochip device

The present invention concerns a luminescent particle comprising a nanoparticle of formulaALnVO(PO)&#x2003;&#x2003;(I)in which A is selected from yttrium (Y), gadolinium (Gd), lanthanum (La), and mixtures thereof; Ln is selected from europium (Eu), dysprosium (Dy), samarium (Sm), neodymium (Nd), erbium (Er), ytterbium (Yb), and mixtures thereof; 0&#x3c;x&#x3c;1; and 0&#x2264;y&#x3c;1; characterized in that the nanoparticle on its surface has tetraalkylammonium cations in an amount such that said nanoparticle has a zeta potential, &#x3b6;, of less than or equal to &#x2212;28 mV in an aqueous medium with a pH&#x2265;5, more particularly with a pH&#x2265;5.5, and with an ionic conductivity &#x3e;100 &#x3bc;S&#xb7;cm. It also concerns a method for preparing such luminescent particles, a colloidal suspension of these particles, and the use thereof as a diagnostic agent, and also a diagnostic kit comprising such luminescent particles.

Luminescent particles based on rare earth elements and use thereof as a diagnostic agent

A method which can be used to analyse oxidising species in a sample, including: placing the sample in contact with a first photoluminescent agent, and a second optically active agent, at least the first photoluminescent agent including nanoparticles doped with rare earth elements and being oxidisable, the luminescence of the first photoluminescent agent varying, at least at one first wavelength, with the amount of oxidising species, and the signal emitted by the second optically active agent being constant or varying, at least at one second wavelength other than the first wavelength, with the amount of oxidising species in a direction opposite to the luminescence of the first photoluminescent agent; energising the first and second agents in the sample; measuring the light intensity of the sample at least at the first and second wavelengths; and assessing the presence and/or the amount of oxidising species by interpreting the measured light intensities.

Method for detecting oxidising species

A method of fabricating a transparent and birefringent mineral solid thin layer comprises the following steps: a) preparing a colloidal solution constituted by anisotropic mineral nanoparticles in suspension in a dispersion liquid; b) depositing the colloidal solution on a surface of a substrate by spreading as a thin layer while applying directional shear stress tangentially to the surface of the substrate so as to deposit the colloidal solution as a liquid thin layer on the surface of the substrate, the value of the shear stress and the concentration of mineral nanoparticles in the colloidal solution being determined in such a manner as to cause the anisotropic mineral nanoparticles to be aligned along the direction of the shear stress tangential to the surface of the substrate; and c) drying the liquid thin layer by evaporating the dispersion liquid.

Method of manufacturing a transparent and birefringent thin solid mineral layer and optic component with a transparent and birefringent thin solid mineral layer

Hydrophobic treatment composition comprising one or more compounds, as a mixture, corresponding to the formula in which

Hydrophobic treatment composition and glazing

The invention relates to a method of producing a substrate which is coated with a mesoporous layer and to the use thereof in ophthalmic optics. The inventive method comprises the following steps comprising: preparing a precursor sol containing (i) a precursor agent that is selected from compounds having formula M(X)4 (I), in which X is a hydrolysable group and M represents silicon or a tetravalent metal and mixtures thereof, (ii) at least one organic solvent, (iii) at least one pore-forming agent and (iv) water; depositing a film of the precursor sol on a main surface of the substrate; optionally consolidating the mesoporous structure of the deposited film; eliminating the pore-forming agent; and recovering the substrate coated with the mesoporous layer. The method is characterized in that: (i) the pore-forming agent is eliminated at a temperature of less than or equal to 150&#xb0; C.; and (ii) the method comprises a step involving the introduction of at least one reactive agent bearing at least one hydrophobic group, before the deposition step and/or after said step.

Method of producing a substrate which is coated with a mesoporous layer and use thereof in ophthalmic optics

The invention relates to a transparent substrate based on glass or one or more polymers, or a ceramic or glass substrate, or a substrate made of architectural material of the type comprising a wall render, a concrete slab or block, architectural concrete, roof tile, material of cementitious composition, terracotta, slate, stone, metal surface or a fibrous substrate, based on glass of the mineral insulation wool type, or glass reinforcement yarns. This substrate is distinguished in that it is provided, on at least part of its surface, with a coating whose mesoporous structure exhibits photocatalytic properties and comprises at least partially crystallized titanium oxide. Process for manufacturing this substrate, its application in glazing, as architectural material or as mineral insulation wool is also described.

Substrate with a self-cleaning coating

This substrate is coated with a composite film based on a mesoporous mineral layer containing nanoparticles formed in situ inside the layer. The composite film has a periodic lattice structure over a major portion of the thickness in which the nanoparticles are present, in which structure the nanoparticles are arranged in a periodic manner on the scale of domains of at least 4 periods in the thickness of the film. This structure can be obtained from a mesoporous mineral layer of periodic structure on the scale of domains of at least 4 periods of pores, forming a matrix on the substrate, by: Applications to materials for electronics, nonlinear optics and magnetism.

Substrate coated with a composite film, method for making same and uses thereof

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Bures sur Yvette, France

Thierry Gacoin