Delalande S.a.

Thierry F Imbert

Bernard P Bucher

Philippe L Dostert

Nicole A Dorme

Claude P Fauran

Guy M Raynaud

Michel J Turin

Michel Langlois

Jean-Francois R Ancher

New derivatives of 3-amino quinuclidine of formula: ##STR1## in which X=sulfur or oxygen; R=H, lower alkyl or benzyl; and Ar=substituted phenyl or substituted pyrimidinyl. These new derivatives have utility in therapeutics as accelerators of the gastro-intestinal motor function and as medicament potentiators.

3-amino quinuclidine derivatives and the application thereof as

There are disclosed nor-tropane derivatives substituted at the 3 position with aroylamino or heteroaroylamino and substituted at the 8 position with benzyl, substituted benzyl, 2-methyl thiophene, 3-methyl thiophene, 2-methyl furan or cyclohexylmethyl. The compounds are prepared by condensing the carboxylic acids corresponding to said aroyl or heteroaroyl group with the corresponding .beta.-3-amino-8-substituted nor-tropanes. The compounds possess neuroleptic properties.

4-Amino-5-bromo-2-methoxy-N-[8-(benzyl)]-8-azabicyclo[3.2.1]

Nor-tropane derivatives

Novel 3 .beta.-aroylamino and 3 .beta.-heteroaroylamino nor-tropanes and granatanes are provided having the general formula: ##STR1## Wherein n=1 or 2, R represents a benzyl or a substituted benzyl group and A-CO represents one of a specific range of aroyl groups. The compounds of the invention are useful in the treatment of psychism or digestive troubles.

Nor-tropane derivatives, and their application in therapeutics

.beta.-3-Amino nor-tropane compounds

Certain nor-tropan-8-amine-3-aryl or heteroaryl derivatives

8-(5-Pyrimidinecarboxamide)nor-tropane derivatives

Compounds for the formula ##STR1## for example, ##STR2## are prepared by reacting ##STR3## with ##STR4## The compounds possess neuroleptic properties.

Amides derived from carboxyl-5 pyrimidines

Compounds of the formula ##STR1## where Ar is phenyl, substituted phenyl, .alpha.-furyl or .alpha.-thienyl, and

1-(2'-Aroyl eth-1'yl) 2-(4'-acetamido piperazine-1'yl methyl)

New 1-(2'-aroyl eth-1' yl) 2-(4'-acetamido piperazine-1' yl methyl)

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Noisy le Roi, France

Thierry F Imbert