Glaxosmithkline Biologicals Sa

Smithkline Beecham Biologicals S.a.

Thierry Coche

Carlota Vinals Y De Bassols

Jean-Pol Cassart

Teresa Elisa Virginia Cabezon-Silva

Swann Romain Jean-Thomas Gaulis

Claudine Elvire Marie Bruck

Remi Palmantier

Gabriele Annemarie Beer

Olivier Gruselle

Dennis Salonga

Craig Lawrence Stephens

James Scott Clark

Frederic Lehmann

Gabriele Anne-Marie Beer

Teresa Elisa Virginia Cabezon Silva

Swann Roman Jean-Thomas Gaulis

The present invention relates to MAGE-3 specific primers and probes for use new diagnostic kits and methods. The invention further relates to immunotherapeutic treatment of specific populations of cancer patients, suffering from MAGE-3 expressing tumors.

Method for the detection and diagnosis of cancer involving primers and probes for the specific detection of the MAGE-A3-marker

CASB7439 polypeptides and polynucleotides, immunogenic compositions comprising them and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing CASB7439 polypeptides and polynucleotides in diagnostics, and vaccines for prophylactic and therapeutic treatment of cancers, particularly colorectal cancers, autoimmune diseases, and related conditions.

Tumor specific animal proteins

Tumour-specific animal proteins

CASB7439 polypeptides and polynucleotides, immunogenic compositions comprising them and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing CASB7439 polypeptides and polynucleotides in diagnostics, and vaccines for prophylactic and therapeutic treatment of cancers, particularly colorectal, breast, and lung cancers, autoimmune diseases, and related conditions.

CASB618 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing CASB618 polypeptides and polynucleotides in diagnostics, and vaccines for prophylactic and therapeutic treatment of cancers, particularly ovarian and colon cancers, autoimmune diseases, and related conditions.

CASB618 polynucleotides and polypeptides and their use

Compositions and methods for the therapy and diagnosis of cancer, particularly lung, colon, colorectal and breast cancer, are disclosed. Illustrative compositions comprise one or more Cripto tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung, colon, colorectal and breast cancer.

Cripto tumour polypeptide

CASB414 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing CASB414 polypeptides and polynucleotides in diagnostics, and vaccines for prophylactic and therapeutic treatment of cancers, particularly colon cancers, autoimmune diseases, and related conditions.

CASB414:antigen overexpressed in several tumors

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Rixensart, Belgium

Thierry Coche