Boehringer Ingelheim International Gmbh

Boehringer Ingelheim Pharma Gmbh & Co Kg

Hydra Biosciences, Inc.

Alkahest, Inc.

Thierry Bouyssou

Andreas Schnapp

Ingo Konetzki

Christoph Hoenke

Klaus Rudolf

Philipp Lustenberger

Claudia Heine

Kurt Schromm

Sabine Pestel

Frank Buettner

Hermann Schollenberger

Domnic Martyres

Niklas Heine

Dirk Gottschling

Ralf Anderskewitz

Michael Robert Turner

Franz Birke

Juergen Mack

Christopher Ronald Sarko

Xinyuan Edward Wu

Lana Louise Smith Keenan

Michael Dennis Lowe

Simon Surprenant

Horst Dollinger

Marco Santagostino

Dieter Wiedenmayer

Hidenori Takahashi

Hossein Razavi

Pascale Pouzet

Peter Seither

Matthias Hoffmann

Henri Doods

Matthias Grauert

Georg Speck

Stephan Georg Mueller

Gerhard Schaenzle

Kirsten Arndt

Michael Paul Pieper

Steffen Breitfelder

Enzo Cereda

Rolf Goeggel

Angela Kay Berry

Matthew Russell Netherton

Michel Pairet

Steven Richard Brunette

Silke Hobbie

Jianwen Cui

Pascale Arielle Jane-Josee Pouzet

Phillip Lustenberger

Paul Nicklin

Michael Chadham Nivens

Steven Brunette

The present invention relates to compounds of formula (I) wherein A, X, R, R, R, Rand Rare as defined herein, and pharmaceutically acceptable salts thereof. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, such as hypertension, preeclampsia, restenosis, a cardiac or respiratory condition, renal disease, liver disease, muscular dystrophy, fibrotic disorders, pain, ischemia or ischemic reperfusion injury, and cancer.

Inhibitors of TRPC6

The invention related to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein Rto R, A, Y and L are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts therefore, wherein Rto R, A, U, V, W, X, Y, and Z are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes. 

The present invention relates to polycyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein Rto R, Rto R, Y and A are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes. 

The invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein Rto R, A, Y and L are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

One object of the present invention are novel substituted piperidyl-propane-thiols of the formula (1), wherein R, R, Rand Rare defined as below. Another object of the present invention is to provide agonists or antagonists of CCR-3, or pharmaceutically acceptable salts thereof, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof. 

Piperidyl-propane-thiol CCR3 modulators

One object of the present invention are novel substituted piperidyl-propane-thiols of the formula (1), wherein R, R, Rand D are defined as below. Another object of the present invention is to provide agonists or antagonists of CCR-3, or pharmaceutically acceptable salts thereof, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof. 

Substituted piperidyl-propane-thiols

A pharmaceutical composition comprising a compound of formula 1 wherein:

Medicaments for the treatment of chronic obstructive pulmonary disease

The invention relates to a method for treating irritable bowel syndrome through the use of effective amounts of a compound acting as CGRP antagonist.

CGRP antagonists

Disclosed are novel piperidine-substituted indoles- or heteroderivatives thereof of the formula 1: wherein R, R, R, R, A, B, D-E, Y, i, j, n and m are defined as below. The compounds of formula 1 are useful as agonists or antagonists of CCR-3. The present invention is also directed to pharmaceutically acceptable salts thereof, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.

Piperidine-substituted indoles

The invention relates to compounds of general formula 1 wherein n, A, B, D, L, R, R, Rand Rmay have the meanings given in the claims and in the specification, processes for preparing them, and their use as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints.

Long acting bronchodilators for the treatment of respiratory diseases

A compound of general formula 1a wherein R, R, R, A, B, Y, i, j and m are defined as in the description and claims. It is another object of the present invention to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.

Alkyl-and piperidine-substituted benzimidazole derivatives

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Mietingen, Germany

Thierry Bouyssou