Devgen Nv

Other

Thierry Andre Oliver Eddy Bogaert

Geert Karel Maria Plaetinck

Jean-Pierre Renard

Qiong Liu

Yee-Ling Khu

Wim Maria Rene Van Criekinge

Michael O Hengartner

Marc Georges Logghe

Marc Van De Craen

Phuay-Yee Goh

Katherine An Hilde Mortier

The present invention concerns methods for controlling fungus infestation via dsRNA mediated gene silencing, whereby the intact fungus cell(s) are contacted with a double-stranded RNA from outside the fungal cell(s) and whereby the double-stranded RNA is taken up by the intact fungal cell(s). In one particular embodiment, the methods of the invention are used to alleviate plants from fungus pests. Alternatively, the methods are used for treating and/or preventing fungal infestation on a substrate or a subject in need of such treatment and/or prevention. Suitable fungal target genes and fragments thereof, dsRNA constructs, recombinant constructs and compositions are disclosed.

Method for down-regulating gene expression in fungi

Improved vector constructs useful in the expression of double-stranded RNA are provided. The constructs are particularly useful for expression of double-stranded RNA in vitro and in vivo.

Vector constructs

The invention relates to a signal transduction pathway which promotes phagocytosis of apoptotic cells and in particular relates to a protein known as CED-6 in the nematode worm , human equivalents of CED-6 protein and nucleic acids encoding them. The invention also relates to use of the proteins and encoding nucleic acids in assay methods for detecting compounds which enhance or inhibit the signal transduction pathway and use of the proteins, nucleic acids and identified enhancer or inhibitor compounds in methods of treatment of human or animal disease.

Engulfment gene and uses thereof

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Kortrijk, Belgium

Thierry Andre Oliver Eddy Bogaert