Galderma Holding Sa

Centre National De La Recherche Scientifique

Galderma Research & Development

Galderma S.a.

Thibaut Gerfaud

Jean-Guy Boiteau

Craig Steven Harris

Loïc Tomas

Johan Olsson

Hotan Mojarradi

Laura Jing Jing

Rachel Auzely-Velty

Tamiris Figueiredo

Lars Nord

Loic Tomas

A new hydrogel made of crosslinked glycosaminoglycans, particularly crosslinked hyaluronic acid, chondroitin or chondroitin sulfate, having reversible linkages using boronic acid or boroxole derivatives leading to new benefits. Glycosaminoglycans that are crosslinked via an alkoxyboronate ester anion formed between a diol portion of a diol-functional moiety grafted to a first glycosaminoglycan and a boronate hemiester grafted to a second glycosaminoglycan.

Method of crosslinking glycosaminoglycans

The invention relates to a hydrogel product comprising glycosaminoglycan molecules as the swellable polymer, wherein the glycosaminoglycan molecules are covalently crosslinked via crosslinks comprising a spacer group selected from the group consisting of di-, tri-, tetra-, and oligosaccharides.

Carbohydrate crosslinker

Enantiomers of butanediol diglycidyl ether (BDDE) are present in an enantiomerically enriched enantioenriched mixture of BDDE stereisomers or in an enantiomerically pure BDDE. Enantiomerically enriched or pure BDDE is useful as a cross-linking agent, such as in the preparation of a cross-linked hyaluronic acid product.

Enantiopure or enantioenriched BDDE and its use as crosslinking agent in the manufacture of cross-linked products

Growing community of inventors

Mouans Sartoux, France

Thibaut Gerfaud