Other

Centre National De La Recherche Scientifique

Institut Pasteur

Cellectis

Université Pierre Et Marie Curie

Institute Pasteur

Therese Ternynck

Stratis Avrameas

Alexandre Avrameas

Gerard Buttin

Susan Michelson

Marie-Francoise Saron

Bruno Blondel

Therese Couderc

Donato Zipeto

Jean-Luc Guesdon

Francois Traincard

Faridabano Nato

Hiroshi Sakamoto

Eustrate Avrameas

Avrameas Stratis

Tuyen Vo Quang

The invention concerns an amino acid sequence capable of facilitating penetration of a substance of interest into cells and/or cell nuclei, characterized in that it is capable of reacting in vivo with aminoglycans. Optionally the sequence is derived from a protein of human origin.

Amino acid sequences facilitating penetration of a substance of interest into cells and/or cell nuclei

The present invention provides novel polypeptides which can effectively penetrate into cells thereby transporting a substance of interest into the cells.

Vectors derived from antibodies for transferring substances into cells

Single-chain antibody fragments for transferring substances into cells

A product for coupling a biologically active principle with an immunovector, characterized in that the immunovector is capable of enabling the biologically active principle to be internalized into eukaryotic cells, and in that said immunovector has an affinity for the cell DNA to such an extent that it can transfer the biologically active principle into or to the immediate vicinity of the cell nuclei.

Immunovectors for the intracellular and intranuclear transport

The invention relates to a new probe for detecting a specified nucleic acid sequence. It consists of a recombinant DNA containing an insert complementary to the nucleic acid sequence to be detected and nuclecic acid sequences derived from the DNA (+) of phage M13, the bases which participate in the composition of this recombinant DNA, in particular the thymine groups, being replaced by 5-bromouracil groups. The invention also relates to a method for manufacturing this probe, this method comprising the culturing of cell hosts, more especially E. coli, which are auxotrophic for thymine in a medium containing a limiting concentration of thymine and containing 5-bromouracil. After the requisite incubation time, the supernatant is removed and the probe is recovered from the bacterial cells.

Non-radioactive labelled single-stranded probe, method for manufacturing

Growing community of inventors

Paris, France

Therese Ternynck