The Texas A&m University System

University of Texas System

Theresa W Fossum

Darrell H Carney

James C Sacchettini

Nian E Zhou

Matthew W Miller

Deeann Wallis

Barbara Olszewska-Pazdrak

Compositions and methods for inhibiting and/or sensitizing or re-sensitizing a parasite to an antiparasitic drug are provided. The compositions can comprise a rifamycin derivative or a pharmaceutically acceptable salt, hydrate, or prodrug thereof in an amount and formulation sufficient to inhibit or induce drug-sensitization in a parasite. The methods can comprise administering a rifamycin derivative or a pharmaceutically acceptable salt, hydrate, or prodrug thereof to a parasite in an amount and formulation sufficient to inhibit or induce drug-sensitization in the parasite.

Compositions and methods for drug sensitization of parasites

Endothelial dysfunction (ED) is associated with a number of diseases and disorders. Agonists of the non-proteolytically activated thrombin receptor can be used in methods to treat ED or ED-related diseases and disorders.

Method of treating endothelial dysfunction comprising administration of a thrombin peptide derivative

Growing community of inventors

College Station, TX, United States of America

Theresa W Fossum