American Cyanamid Company

Theresa Rice Haughey

Susan Mancini Cady

William David Steber

David Farley Johnson

The invention relates to implants for the parenteral administration of an essentially uniform and continuous amount of a biologically active protein, peptide or polypeptide over an extended period of time which comprises a compacted, indented and partially coated composition containing from one to three layers of a homogeneous core mixture comprising about 20% to about 80% of a biologically active protein, a peptide or a polypeptide; about 10% to about 75% of a fat, a wax or a mixture thereof; 0% to about 25% of a buffer, a salt, a sugar or a mixture thereof; 0% to about 15% of a filler, on a weight basis of the total weight of the core mixture. The partial coating of a semipermeable material comprises about 5% to about 50%, on a weight basis of the total weight of the implant. The invention also relates to methods for increasing and maintaining elevated blood levels of biologically active proteins, peptides and polypeptides in animals by the administration of said implants.

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Raleigh, NC, United States of America

Theresa Rice Haughey