Entremed, Inc.

Celldex Therapeutics Limited

Theresa Marie LaVallee

Jamshed H Shah

Anthony Treston

Gregory E Agoston

Gerald McMahon

Victor S Pribluda

Lita Suwandi

Shawn J Green

Kimberly A Hunsucker

Christopher J Herbstritt

Xiaoguo H Zhan

Provided herein are methods and uses involving antibodies that specifically bind to a KIT receptor tyrosine kinase for managing, treating, or preventing an eosinophil or mast cell related disorder and/or one or more symptoms thereof, for example a mast cell related disorder of the nervous system, e.g., central nervous system, for example neuromyelitis optica (NMO), neuromyelitis optica spectrum disorder (NMOSD), multiple sclerosis (MS), and neurofibromatosis (NF).

Treatment of eosinophil or mast cell related disorders

Compositions and methods for treating mammalian diseases or conditions characterized by undesirable angiogenesis by administering an effective amount of a compound of the formulae: wherein Ris selected from &#x2014;OCH, &#x2014;OCHCHor &#x2014;CCCH; and Z is selected from &#x3e;C(H)&#x2014;OH, &#x3e;C(H)&#x2014;O-alkyl, &#x3e;C(H)&#x2014;O-sulfamate, where alkyl is a linear, branched and/or cyclic hydrocarbon chain comprising 1 to 10 carbons.

Methods of treating disease states using antiangiogenic agents

Antiangiogenic agents

Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering compounds of the general formula: wherein the variables are defined in the specification.

Estradiol derivatives and pharmaceutical compositions using same

Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering derivatives of 2-methoxyestradiol of the general formula: wherein the variables are defined in the specification.

Growing community of inventors

Rockville, MD, United States of America

Theresa Marie LaVallee