Karo Bio Ab

Karo Pharma Ab

Theresa Apelqvist

Sandra Gordon

Aiping Cheng

Johan Malm

Peter Brandt

Chris Litten

Karin Edvinsson

Patrik Rhönnstad

Mattias Wennerstål

Asa Hedfors

Elisabet Kallin

Konrad Koehler

Lars Hagberg

Erik Holmgren

Patrick Goede

Jinchang Wu

Mattias WENNERSTÅL

Patrik RHÖNNSTAD

The invention provides a compound of formula(I) or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt. The invention also provides the use of such compounds in the treatment or prophylaxis of a condition associated with a disease or disorder associated with estrogen receptor activity. Formula(I) wherein R, R, R, R, R, R, R, R, Rand Rare as defined in the specification. 

Estrogen receptor ligands

The invention provides a compound of formula (I) or a pharmaceutically acceptable ester, amide, carbamate, solvate or salt thereof, including a salt of such an ester, amide or carbamate, and a solvate of such an ester, amide, carbamate or salt. The invention also provides also provides the use of such compounds in the treatment or prophylaxis of a condition associated with a disease or disorder associated with estrogen receptor activity, wherein R, R, R, Rand Rare as defined in the specification. 

The invention provides a compound of formula (I) or a pharmaceutically acceptable ester, amide, carbamate, solvate or salt thereof, including a salt of such an ester, amide or carbamate, and a solvate of such an ester, amide, carbamate or salt. The invention also provides also provides the use of such compounds in the treatment or prophylaxis of a condition associated with a disease or disorder associated with estrogen receptor activity, wherein R, R, R, R, Rand Rare as defined in the specification. 

This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac arrhythmias, thyrotoxicosis and subclinical hyperthyrodism.

Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders

Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders

Liver specific bile acid derivatives of the glucocorticoid antagonist RU486

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Grödinge, Sweden

Theresa Apelqvist