Gist-brocades N.v.

Theodorus K Jurriens

Cornelis A Bruynes

A novel process for the preparation of thioethers comprising reacting a silylated thiol of the formula

Preparation of thioethers

An improved process for the trimethylsilylation of organic compounds with at least one active hydrogen atom with hexamethyldisilazane, the improvement comprising effecting the reaction in the presence of 0.001 to 10 mole percent of a catalyst of the formula

Silylation process

A novel process for the preparation of 7-acylamino-3-(thio-substituted)-methyl-3-cephem-4-carboxylic acid 1-oxide derivatives comprising reacting a 7-acylamino-3-bromomethyl-3-cephem-4-carboxylic acid-1-oxide derivative with a silylated thiol of the formula

Preparation of 7-acylamino-3-(thio-substituted)-methyl

An improved process for the preparation of 3'-bromo-desacetoxycephalosphoranic acid sulfoxide compounds comprising protecting the 4-carboxy group of a 3'-unsubstituted cephalosporanic acid sulfoxide by silylating in an inert anhydrous organic solvent and brominating the silylated compound in situ which 3'-bromo compounds are valuable intermediates for the preparation of therapeutically useful cephalosporanic acid compounds.

Growing community of inventors

Delft, Netherlands

Theodorus K Jurriens