Janssen Vaccines & Prevention B.v.

Theodorus Hendrikus Kwaks

Richard George Sewalt

Henricus Johannes Van Blokland

Arie Pieter Otte

Robert Heinz Friesen

Ronald Vogels

Mark Throsby

David Adrianus Theodorus Maria Zuijdgeest

Robert H E Friesen

David Atm Zuijdgeest

Arie Otte

Mandy Antonia Jongeneelen

Described are binding molecules, such as human monoclonal antibodies, that bind to an epitope in the stem region of hemagglutinin of influenza A viruses of phylogenetic group 1 and group 2, as well as influenza B viruses, and have a broad neutralizing activity against such influenza viruses. Provided are nucleic acid molecules encoding the binding molecules, their sequences, and compositions comprising the binding molecules. The binding molecules can be used, for example, in the diagnosis, prophylaxis, and/or treatment of influenza A viruses of phylogenetic groups 1 and 2, as well as influenza B viruses.

Human binding molecules capable of neutralizing influenza A viruses of phylogenetic group 1 and phylogenetic group 2 and influenza B viruses

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Voorschoten, Netherlands

Theodorus Hendrikus Kwaks