Janssen Vaccines & Prevention B.v.

Theodorus Hendrikus Kwaks

Ronald Vogels

David Adrianus Theodorus Maria Zuijdgeest

Robert H E Friesen

Described are binding molecules, such as human monoclonal antibodies, that bind to an epitope in the stem region of hemagglutinin of influenza A viruses of phylogenetic group 1 and group 2, as well as influenza B viruses, and have a broad neutralizing activity against such influenza viruses. Provided are nucleic acid molecules encoding the binding molecules, their sequences, and compositions comprising the binding molecules. The binding molecules can be used, for example, in the diagnosis, prophylaxis, and/or treatment of influenza A viruses of phylogenetic groups 1 and 2, as well as influenza B viruses.

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Voorschoten, Netherlands

Theodorus Hendrikus Kwaks