Janssen Pharmaceutica Nv

Theodorus Dinklo

Johannes Wilhelmus John F Thuring

Anne Simone Josephine Lesage

Gregor James MacDonald

Marcel Frans Leopold De Bruyn

Wei Zhuang

Yves Emiel Maria Van Roosbroeck

Frans Alfons Maria Van Den Keybus

James Edward Stewart Duffy

Anne Simone Lesage

Christopher James Grantham

Gregor James Macdonald

Johannes Wilhelmus Thuring

Frans Alfons Van Den Keybus

Yves Emiel Van Roosbroeck

Marcel Frans De Bruyn

James Edward Duffy

This invention concerns the use of a compound of formula (I) 

2-aniline-4-aryl substituted thiazole derivatives

The present invention relates to substituted 1-(alkyl)-3-aniline-5-aryl triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I).  The invention particularly relates to potent positive allosteric modulators of nicotinic acetylcholine receptors which have the capability of increasing the efficacy of nicotinic receptor agonists.

Trisubstituted 1,2,4 triazoles

The present invention relates to 2-[3-(2,2-Difluoro-benzo[1,3]dioxol-5-ylamino)-5-(2,6-dimethyl-pyridin-4-yl)-[1,2,4]triazol-1-yl]-N-ethyl-acetamide and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy.  The invention particularly relates to a potent positive allosteric modulator of nicotinic acetylcholine receptors which have the capability of increasing the efficacy of nicotinic receptor agonists.

1,3,5-trisubstituted triazole derivative

The present invention relates to 3-aniline-5-aryl triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I).  The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.

Trisubstituted 1,2,4-triazoles

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Theodorus Dinklo