Innocore Technologies B.v.

Ophtec B.v.

Stryker European Holdings I LLC

Stryker European Operations Holdings LLC

Ingell Technologies Holding B.v.

Polyganics Bv

Polyvation B.v.

Polyvation Cosmeterials B.v.

Innocore Technologies Holding B.v.

Theodorus Adrianus Cornelius Flipsen

Catharina Everdina Hissink

Johan Zuidema

Rob Steendam

Linda Joan Gibcus

Hendrik Smit

Ronald Meyboom

Miriam Adrienne Lambertina Verbruggen

Herbert Wilhelm Ulmer

Joke Geesje Hagting

Christine Hiemstra

Eelco Christoffer Brian Van Der Flier

Ronald Meijboom

Hans Wicher Kuijper

Maarten Van Dijk

Esther De Boef

Paul Marcel Van Midwoud

The invention relates, generally, to porous absorbent materials which are suitable for packing antrums or other cavities of the human or animal body. More particularly, it relates to hydrophilic biodegradable foams, which may be used e.g. in the form of a plug or tampon, for instance for controlling bleeding, wound closure, prevent tissue adhesion and/or support tissue regeneration. The invention provides an absorbent foam, suitable for packing antrums or other cavities of the human or animal body, comprising a biodegradable synthetic polymer, which polymer preferably comprises —C(O)—O—groups in the backbone of the polymer, for instance polyurethane and/or polyester units combined with polyethers.

Biomedical foams

The invention relates to the fields of microbiology and health care, in particular to means and methods for minimizing the spread of hospital-acquired (HA) infections e.g. between patients and healthcare workers. Provided is an antimicrobial composition comprising an antimicrobial agent, a pharmaceutically acceptable carrier material and a polymer, the polymer being an N-vinyl lactam copolymer, and the composition being capable of forming a slow release antimicrobial film when applied to a skin surface.

Antimicrobial compositions and methods for reducing microbial contamination

The invention relates, generally, to porous absorbent materials which are suitable for packing antrums or other cavities of the human or animal body. More particularly, it relates to hydrophilic biodegradable foams, which may be used e.g. in the form of a plug or tampon, for instance for controlling bleeding, wound closure, prevent tissue adhesion and/or support tissue regeneration. The invention provides an absorbent foam, suitable for packing antrums or other cavities of the human or animal body, comprising a biodegradable synthetic polymer, which polymer preferably comprises &#x2014;C(O)&#x2014;O&#x2014; groups in the backbone of the polymer, for instance polyurethane and/or polyester units combined with polyethers.

The invention relates to copolymers of vinyl lactams with derivatized maleates. In particular, it relates to copolymers that are suitably used in the area of personal care and pharmaceuticals, to compositions comprising the copolymers and to methods for preparing the copolymers.

Maleate-based copolymers and methods for preparing the same

A composition including a) 55-98.9 wt % of at least one type of triblock copolymer (A) of formula (1)R&#x2014;B-A-B&#x2014;R&#x2003;&#x2003;(1)b) 0.1-15 wt % of at least one surfactant (B) and c) 1-30 wt % of water, wherein A is a hydrophilic block having a number average molecular weight (Mn) of 100-1,000 Da, B is a hydrophobic block made from monomers having at least a monomer B1 and a monomer B2, wherein B1 and B2 have the largest weight contents in the hydrophobic block and B1 has a lower molecular weight than B2, wherein R is an end group which is H or a C1-C30 organic moiety, wherein the composition is fluid in a temperature range of 0&#xb0; C. to 37&#xb0; C., wherein the weight % are relative to the sum of a), b) and c), and wherein the sum of components a), b) and c) is at least 80 wt % of the entire composition, preferably at least 90 wt %; to the use of the composition and to pharmaceutical compositions having said composition and an active pharmaceutical ingredient.

Compositions comprising triblock copolymers

This invention is directed to a biodegradable, semi-crystalline, phase separated thermoplastic multi-block copolymer, a process for preparing said multi-block copolymer, a composition for the delivery of at least one biological active compound, and to a method for delivering a biologically active compound to a subject in need thereof. A multi-block copolymer of the invention is characterized in that:

Biodegradable, semi-crystalline, phase separated, thermoplastic multi block copolymers for controlled release of biologically active compounds

The invention relates, generally, to porous absorbent materials which are suitable for packing antrums or other cavities of the human or animal body. More particularly, it relates to hydrophilic biodegradable foams, which may be used, e.g., in the form of a plug or tampon, for instance for controlling bleeding, wound closure, prevent tissue adhesion and/or support tissue regeneration. The invention provides an absorbent foam, suitable for packing antrums or other cavities of the human or animal body, comprising a biodegradable synthetic polymer, which polymer comprises &#x2014;C(O)&#x2014;O&#x2014; groups in the backbone of the polymer, for instance polyurethane and/or polyester units combined with polyethers.

The invention is directed to biodegradable, thermoplastic, phase separated segmented multi-block copolymers. The copolymers of the present invention find use in various biomedical applications as well as in pharmaceutical applications. Provided is a composition for the controlled release of at least one biologically active polypeptide to a host, comprising the at least one biologically active polypeptide encapsulated in a matrix comprising at least one phase separated, thermoplastic multi-block copolymer, the copolymer being characterized in that (i) it comprises at least two hydrolysable segments chosen from prepolymer (A) and prepolymer (B), prepolymer (A) having a Tg lower than 37&#xb0; C. and prepolymer (B) having a Tm of 40&#xb0; C.-100&#xb0; C. under physiological conditions; (ii) the segments being linked by a multifunctional chain-extender; (iii) the segments are randomly distributed over the polymer chain; and (iv) prepolymer (A) contains a segment that is derived from a water soluble polymer.

Biodegradable phase separated segmented multi block co-polymers and release of biologically active polypeptides

The invention relates to a biodegradable multi-block copolymer, comprising at least two hydrolysable segments derived from pre-polymers A and B, which segments are linked by a multi-functional chain-extender and are chosen from the pre-polymers A and B, and triblock copolymers ABA and BAB, wherein the multi-block copolymer is amorphous at physiological (body) conditions. The invention further relates to a process for preparing said copolymer and to its use as a medical implant, a coating for a medical device or a drug delivery vehicle.

Biodegradable multi-block co-polymers

The invention is directed to biodegradable, thermoplastic, phase separated segmented multi-block copolymers. The copolymers of the present invention find use in various biomedical applications as well as in pharmaceutical applications. According to the invention, a biodegradable, phase separated copolymer is provided, comprising segments of a soft prepolymer (A) having a glass transition temperature, Tg, lower than 37&#xb0; C.; and segments of a hard prepolymer (B) having a phase transition temperature, Tm, of 40-100&#xb0; C.

Biodegradable phase separated segmented multi block co-polymers

The present invention relates to specific DL-lactide-&#x3b5;-caprolactone copolymers and the application of these polymers in the production of biodegradable medical applications. According to the present invention a polymeric material comprising poly(DL-lactide-co-&#x3b5;-caprolactone) is provided, which is obtained by the copolymerization of DL-lactide and &#x3b5;-caprolactone, having a lactide content of 51-75 mol %, most preferably of 62-69 mol %.

DL-lactide-&#x3b5;-caprolactone copolymers

The present invention discloses to a high refractive index polysiloxane (co)polymer comprising refractive index modifying groups chemically bonded in clustered configuration to the polysiloxane backbone. The invention also discloses methods for the preparation of such high refractive index polysiloxane (co)polymers A polysiloxane according to the invention is very suitable for use as a material for the production of intra-ocular lenses.

High refractive index flexible silicone

The invention relates to transparent polymer material containing a dye which absorbs light above 400 nm. It furthermore relates to methods for producing the polymer material and a lens comprising the polymer material. In particular, the invention relates to an intraocular lens (IOL) suitable for implantation in mammals, which IOL has visible light transmission properties comparable to those of the human crystalline lens. Provided is a transparent polymer material containing at least one covalently attached dye, said dye having the general formula I: 

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Groningen, Netherlands

Theodorus Adrianus Cornelius Flipsen