Spinesmith Partners, L.p.

Theodore Sand

Kevin Dunworth

Matthew Murphy

John B Rossman

David John Sayler

Joshua King Hoyt

Paul DeKoning

Greg Hinzmann

Melissa Samano

Richard Suzuki

Eileen Dawson

Katy Moncivais

Brian D Burkinshaw

Richard J Kana

Bartley A Johnson

Michelle Kelly

Jessica Terrazas

Kathryn Moncivais

Colan Partee

The invention is directed to a bone void filler comprising a scaffold or matrix. The scaffold or matrix may include a porous inorganic matrix component and/or a 3D-printed implantable device. The bone void filler may include a cellular component containing cells, some of which are capable of making extracellular matrix resembling native bone tissue. The bone void filler may include an organic matrix, such as, an organic biopolymer that aids in cell retention and renders the scaffold or matrix moldable. The bone void filler may include growth factors and/or cytokines. The bone void filler may include a clotting agent.

Treatment of skeletal voids with implantable substrate hydrated with bone marrow concentrate

The invention is directed to a device for the concentration of fluids comprising a donor receptacle containing a fluid to be concentrated, the donor receptacle comprising a plunger; a receiving receptacle to receive the concentrated fluid, the receiving receptacle comprising a plunger; a concentrator device that is connected to the donor receptacle and the receiving receptacle; and a housing that encloses the donor and receiving receptacles and the concentrator device that the plungers of the donor and receiving receptacles are enclosed within chambers that are gas tight.

Automated device for point-of-care cell processing

The invention is directed to a bone void filler comprising a scaffold or matrix. The scaffold or matrix may include a porous inorganic matrix component. The bone void filler may include a cellular component containing cells, some of which are capable of making extracellular matrix resembling native bone tissue. The bone void filler may include an organic matrix, such as, an organic biopolymer that aids in cell retention and renders the scaffold or matrix moldable. The bone void filler may include growth factors and/or cytokines. The bone void filler may include a clotting agent.

Embodiments of the invention is directed to methods of forming a bone-like material, by placing a matrix into a culture container, adding cells to the matrix, placing the tissue-cell construct into the culturing environment and incubating the construct under appropriate conditions for the time required to produce an amount of bone-like material of sufficient volume to be harvested for further processing. Other embodiments of the invention are directed to the use of the bone-like material formed by methods of the invention in implantation procedures.

In vitro production of bone-like material

A composite bone graft which comprises an allograft bone component; a synthetic bone substitute, wherein the synthetic bone substitute is in contact with the allograft bone component. The composite is arranged within a resorbable mesh casing.

Composite bone graft device

The invention comprises a combination of biological elements that will naturally remodel in vivo based on applied mechanical forces. The final composition will possess mechanical properties similar to cartilage or a disc, and significantly less stiff than bone or implants comprised of metals or plastics. The equilibrium stress conduction will minimize unnatural forces on neighboring healthy discs.

Mesenchymal cell-based soft fusion as a biological intervertebral disc replacement

The invention is directed to a work station for use in performing processing of patient samples, storing equipment and drugs in a hospital and the like, the cart having a lower housing having caster wheels mounted on the bottom thereof, the lower housing having angular-shaped side panels therearound which may be opened for entrance into all sides of the housing, and one or more of the side panels; an upper housing mounted on top of the lower housing, the upper housing having one or more side panels therearound; and one or more work areas mounted on top of the upper housing, the shelf adapted for receiving point-of-care equipment.

Automated work station for point-of-care cell and biological fluid processing

The invention is directed to a method for isolating stromal cells to form a therapeutic composition; and administering said therapeutic composition to the subject. A further embodiment of the invention is directed to therapeutic compositions comprising isolated stromal cells.

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Austin, TX, United States of America

Theodore Sand