University of Michigan

Theodore S Lawrence

Mukesh K Nyati

Jason Christopher Rech

Christopher Whitehead

Brennan Taylor Watch

Provided herein are compounds that modulate EGFR and methods of using the same, for example to treat cancer.

EGFR dimer disruptors and use of the same

Provided herein are compounds that inhibit a binding interaction between an epidermal growth factor receptor (EGFR) and a heat shock protein 90 (HSP90), as well as compositions, e.g., pharmaceutical compositions, comprising the same, and related kits. In some embodiments, the compound is an antibody or antibody analog, and, in other embodiments, the compound is a peptide or peptide analog. Also provided are methods of using the compounds, including methods of increasing degradation of an EGFR, methods of treating cancer, and methods of sensitizing tumors to radiation therapy.

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Ann Arbor, MI, United States of America

Theodore S Lawrence