Other

Nexstar Pharmaceuticals, Inc.

Replidyne, Inc.

Theodore M Tarasow

Bruce Eaton

Jian Qiu

Richard Lewis Jarvest

Joseph Guiles

John Michael Berge

Dan Nieuwlandt

Torin Dewey

Catherine Simone Victoire Frydrych

The present invention provides methods for identifying (3-amino-2-oxo-azetidin-1-yl) acetic acid derivatives with anti-PBP2a activity. The method involves the selection of RNA biocatalysts that promote the formation of (3-amino-2-oxo-azetidin-1-yl) acetic acid derivatives with anti-PBP2a activity from component reactants. The invention also provides novel (3-amino-2-oxo-azetidin-1-yl) acetic acid derivatives with anti-PBP2a activity identified by these methods. The invention also provides RNA biocatalysts that are capable of catalyzing the formation of (3-amino-2-oxo-azetidin-1-yl) acetic acid derivatives from component reactants.

Antibiotic compounds

Novel substituted thiophenes that are inhibitors of bacterial methionyl t-RNA synthetase (MRS) are disclosed. Also disclosed are method for their preparation and their use in therapy as anti-bacterial agents.

Substituted thiophenes with antibacterial activity

This invention discloses a method for coevolving products from two or more reactants, along with the nucleic acid that can facilitate the reaction for making the products. The invention further discloses the products and facilitating nucleic acids produced by said method.

Parallel SELEX.TM.

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Longmont, CO, United States of America

Theodore M Tarasow