The Upjohn Co.

Other

Theodore J Roseman

Richard W Baker

James W Ayres

Gilbert Schwartzman

Osmer C Carpenter

Osmer S Carpenter

Glenford R Derr

A medicated device comprises a substantially cylindrical, hollow body member having radially outwardly extending annular ridges at each end, a lengthwise slot, and inwardly extending flanges along the edges of the slot which have concave facing surfaces. A multi-layer, drug-bearing sheet material extends around the cylindrical member between and adjacent the annular ridges and has edge portions which extend into the slot. A cylindrical rod is disposed between the concave surfaces to clamp the sheet edge portions in the slot against the concave surfaces. End caps are mounted on each end of the cylindrical member, and each has a radially inwardly extending ridge which presses an adjacent edge of the sheet material against the cylindrical member.

Medicated device holder

The present specification describes a medicated device adapted for a single and rate-controlled rectal or vaginal administration to a mammal of a systemically active pharmaceutical (SAP). The device accomplishes drug administration at an essentially time-independent rate of dosage. Further, the device advantageously results in the substantial exhaustion of the SAP from the device at the conclusion of the single, acute use. The device comprises three elements:

Two-member medicated device for rate-controlled administration of

The present specification describes a medicated device adapted for a single, acute, and rate-controlled rectal or vaginal administration to a mammal of a lipophilic prostaglandin. The device accomplishes drug administration at an essentially time-independent rate of dosage. Further, the device advantageously results in the substantial exhaustion of the prostaglandin from the device at the conclusion of the single, acute use. The device comprises three elements:

Two-membrane medicated device for rate-controlled administration of

Novel vaginal devices containing prostaglandins and intended for use in accomplishing abortion in women in the first and second trimester of pregnancy and in inducing labor in pregnant women at or near term.

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Portage, MI, United States of America

Theodore J Roseman