Isi Life Sciences, Inc.

Theodore Hessler, Iii

Robert M Moriarty

Gerald F Swiss

Richard J Pariza

David M White

John Fante

Craig Keshishian

This invention is directed to methods for the facile and accurate identification of cancer cells in a tissue sample, such as a surgical field. In particular, the compositions and methods employ conjugates comprising pro-fluorescent fluorescein based moieties bound to folic or pteroic acid targeting moiety optionally through a linker. The pro-fluorescent fluorescein based moieties are non-fluorescent but capable of being rendered fluorescent by intracellular processes. The conjugates are employed to detect cancer cells that overexpress folic acid receptors thereby providing for differential accumulation of these conjugates in these cells.

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Newport Beach, CA, United States of America

Theodore Hessler, Iii