Tetragenetics, Inc.

Cornell Research Foundation Inc.

University of Georgia Research Foundation, Inc.

The University of Chicago

Theodore G Clark

Paul A Colussi

Ashot Papoyan

Harry W Dickerson, Jr

Yelena Bisharyan

Harold G Craighead

William Don Harriman

Hans De Haard

Yung-fu Chang

Ellen J Collarini

Lore Mariën

David M Lin

Jacek Gaertig

Jose Manuel Moran-Mirabal

Aaron Turkewitz

Donna Cassidy-Hanley

Kyle Anderson

Reid N Orth

Tian-Long Lin

Janna Bednenko

Joanna Cardarelli

Douglas Kahn

Bas Van Der Woning

Alka Agrawal

Paul Colussi

Anti-Kv1.3 antibodies (mAbs), particularly mAbs that specifically bind to Kv1.3 with high affinity and/or inhibit Kv1.3 function, are disclosed. The amino acid sequences of the CDRs of the light chains and the heavy chains, as well as consensus sequences for these CDRs, of these anti-Kv1.3 mAbs are provided. Additionally, canonical structures for CDRs in the VH and VL regions of anti-Kv1.3 antibodies are provided. The disclosure also provides nucleic acid molecules encoding the anti-Kv1.3 mAbs, expression vectors, host cells, methods for making the anti-Kv1.3 mAbs, and methods for expressing the anti-Kv1.3 mAbs. Finally, methods of using the anti-Kv1.3 mAbs as therapeutics, such as for preventing or treating an autoimmune disorder, are disclosed.

Anti-Kv1.3 antibodies, and methods of production and use thereof

This invention is directed to methods for the production of immunogenic granular particles. In certain embodiments, the invention is directed to methods and products for the production of immunogenic granular particles produced in ciliates. In certain embodiments, the invention is directed to compositions comprising Granule lattice protein/Antigen(Grl/Ag) fusion polypeptides.

Fusion proteins of ciliate granule lattice proteins, granular protein particles thereof, and uses therefor

This invention is directed to methods for recombinant polypeptide production and, in particular, methods and products for the production and purification of recombinant proteins in ciliates.

Production of recombinant proteins in ciliates and uses thereof

This invention is directed to methods for recombinant polypeptide production and, in particular, methods and products for the production of recombinant polypeptides in ciliates.

Polypeptide expression in ciliates

An array is formed with a protective cover on a substrate. The protective cover is patterned to produce an array of openings to the substrate. Desired material is deposited on the substrate through the openings. The protective cover may then be removed. In one embodiment, the protective cover is a conformal polymer, such as di-para-xylylene. It may be removed by mechanical peeling. The material may be biological material such as DNA. The protective cover may be used to prevent non-specific hybridization in inter-spot regions by performing hybridization with the cover still in place. Hybridization that occurs in such regions between the spots may be removed with removal of the protective cover.

Protective coating for array material deposition

A novel i-antigen protein fromis effective to induce a protective immune response in fish. The invention includes antigenic and membrane-targeting sequences of i-antigen proteins, nucleic acid molecules that encode antigenic or membrane-targeting portions of i-antigen proteins, DNA and protein subunit vaccines, methods of inducing an immune response in fish and methods for detection and characterization of

Diagnostic and protective antigen gene sequences of ichthyophthirius

The ciliated protozoan Tetrahymena exemplifies a recombinant system for the expression of heterologous nucleic acids, preferably on the plasma membrane surface. Integration of a heterlogous nucleic acid into the &#x3b2;-tubulin gene, BTU1, of a paclitaxel-sensitivemutant that possesses btu1-1K350M &#x3b2;-tubulin allele allows screening for transformants using negative selection, as transformants have restored paclitaxel resistance. Transgenic ciliated protozoa of the invention can serve as live vaccines. For example, transgenic Tetrahymena expressingi-antigen protein on their surface are effective vehicles for vaccination of freshwater fish against infection by

Recombinant expression of heterologous nucleic acids in protozoa

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Ithaca, NY, United States of America

Theodore G Clark