Zymogenetics, Inc.

Bristol-myers Squibb Compnay

Theodore E Whitmore

Scott R Presnell

Wayne R Kindsvogel

Cindy A Sprecher

Joseph Leon Kuijper

Zeren Gao

Francis J Grant

Julia E Novak

Mark F Maurer

Jane A Gross

Stacey R Dillon

Angela K Hammond

Maria M Dasovich

Si Lok

Robyn L Adams

Anna C Jelmberg

Theresa M Farrah

Choon J Kho

Donald C Foster

Wenfeng Xu

Kevin M Klucher

Teresa Gilbert

James L Holloway

Joyce M Lehner

Emily C Costerison

Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

Methods of producing a zcytor17 heterodimeric cytokine receptor

ZCYTOR17 heterodimeric cytokine receptor

Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

Polynucleotides encoding antibodies to cytokine receptor zcytor17

ZCYTOR17 heterodimeric cytokine receptor polynucleotides

Antibodies to cytokine receptor ZCYTOR17

Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zyctor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zyctor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

Nucleic acid encoding cytokine receptor ZCYTOR17

Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor19, are located on chromosome 1p36.11, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

Methods of detecting cancer with antibodies to cytokine receptor ZCYTOR19

Polynucleotides encoding cytokine receptor zcytor19

Cytokine receptor zcytor19

Cytokine receptor zcytor17

Polynucleotide encoding cytokine receptor zcytor17 multimer

Nucleic acid encoding cytokine receptor zcytor17

Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in kidneys, pancreas, prostate, adrenal cortex and nervous tissue. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of these organs.

Class II cytokine receptor-7

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Redmond, WA, United States of America

Theodore E Whitmore