The Dow Chemical Company

Michigan State University

Dowelanco

Kemeta, LLC

Theodore E Miller, Jr

Hamish Small

Timothy S Stevens

Charles M Davis

Ziad Iskandarani

Gregory L Charvat

James A McIntyre

Ray W Chrisman

Alan D Strickland

Frank L Saunders

Robert E LaPointe

Paul E Cranley

Jeffrey Allen

Venkiteswaran Subramanian

Tonja R Sutton

Kristine L Danowski

Malcolm W Warren, Ii

Eugene L Liening

Bettina M Rosner

Larry Sun

Charles J Latta

Melanie C Poon

Bradley C Schuchardt

Thomas A Skokut

Alan R Gould

Karen D Quinn

Leo C Kempel

Kenneth M Cabala

David R Bell

Charles A Nielsen

Described are enzyme systems specific for acetone and methods of using these enzyme systems to detect acetone in biological or environmental samples. Biosensors containing these enzyme systems are disclosed, in which detection of acetone may be achieved by linking electrochemical, photometric, or other detection means to one or more acetone-specific enzyme reactions or pathways. Methods of using such acetone-specific biosensors include subject management of weight loss, disease detection, and bioavailability monitoring of therapeutics. 

Enzyme-based system and sensor for measuring acetone

A method for detecting a latent environmental effect (such as a corrosive environment under insulation) or a latent structural change (such as a crack in a concealed structural member) at a known remote concealed location. The method of the instant invention includes three steps. The first step is to use a harmonic electromagnetic transponder at the known remote concealed location of the latent environmental effect or the latent structural change, the harmonic electromagnetic transponder having a reactive portion which reacts to the latent environmental effect or latent structural change to modify the harmonic emission of the transponder. The second step is to remotely interrogate the transponder by directing electromagnetic radiation at the transponder. The third step is to use the harmonic emission of the transponder to remotely determine the latent environmental effect or the latent structural change.

Harmonic wireless transponder sensor and method

A thermal method for studying chemical responses, such as catalyzed polymerization reactions that includes the following three steps. The first step is to flow a chemical substance through a conduit, the conduit being in thermal communication with an electrical conductor, the electrical conductor being co-linear with the conduit, the electrical resistance of the electrical conductor being a function of the temperature of the electrical conductor. A length of stainless steel tubing can be used as both the conduit and the conductor. The second step is to flow electricity through the electrical conductor during the first step. The third step is to measure the electrical resistance of the electrical conductor during the second step to determine any change in the temperature of the conduit caused by a response of the chemical substance. An apparatus for studying chemical reactions that includes: a first conduit, the first conduit being an electrical conductor, the first conduit having a first end and a second end, the electrical resistance of the first conduit being a function of the temperature of the first conduit; a source of electricity, the source of electricity in electrical communication with the first conduit so that electricity can be flowed through the first conduit; a volt meter in electrical communication with the first conduit so that the voltage measured by the volt meter is an indication of the temperature of the first conduit.

Thermal method and apparatus

A method and apparatus for determining a physical property of a gas in a confined space. Gas of known volume, pressure and temperature is placed in communication with a confined space containing gas at known pressure to determine the volume of gas in the confined space using computations based on the gas laws. Alternatively, gas of known pressure, volume, and temperature may be placed in communication with a confined space containing gas at known volume to determine the pressure of gas in the confined space prior to communication with the gas of known properties. Gas volume determinations are useful, for example, to perform rheological characterizations of liquid samples.

Method and apparatus for determining physical properties of a gas for

A liquid chromatographic method and apparatus is disclosed which employs an improved pump not requiring driven pistons or sliding seals. The pump comprises at least one length of tubing forming a chamber disposed between first and second check valves, controllable heating means to periodically heat liquid in said chamber effective to pump relatively low volumes of liquid from the chamber at relatively high pressures, means for measuring the pressure developed by the pump, and control means to increase and decrease the amount of heat imparted to the liquid to maintain the pump operation at a controlled pressure setpoint.

Liquid chromatographic pump

A method of determining individual ion concentrations in mixtures using ion exchange separation combined with indirect photometric detection and frontal analysis.

Method for sensing individual ion concentrations within mixtures using

An apparatus and method are taught for the acceleration of a propellable matter at selected target matter.

Method and apparatus for the acceleration of a propellable matter

A chemical analysis method for indirect detection thin layer chromatography of cations that provides a rapid indication of the amount and type of cation present with minimal equipment requirements. The method includes four steps. The first step is to equilibrate a thin layer cation exchange chromatography plate with a color-forming cation, such as with copper II, to form a prepared plate. The second step is to deposit a sample on the prepared plate to form a spotted plate, the sample containing a cation of interest, such as sodium I. The third step is to develop the spotted plate with a liquid solution containing the color-forming cation, such as a solution of copper II ions, to chromatograph the cation of the sample to form a developed plate. The last step is to expose the developed plate to a chemical agent, such as ammonia, to visualize the color-forming cation by a chemical reaction between the chemical agent and the color-forming cation to form a colored species, such as the blue colored copper II/ammonia complex. When this is done, the chromatographed sample cation is apparent as region of less intense color in a field of color on the plate generated by the colored species.

Indirect detection thin layer chromatography of cations

Material is supplied to a mold by direct application of gas pressure to a liquid material. A method for the shaping of at least two different synthetic resinous materials by providing a predetermined quantity of up to about 100 cm.sup.3 of a first material in a first material reservoir and a second material in a second material reservoir, the first and second material reservoirs each being in communication with a discharge line having a sufficiently narrow inner diameter such that each reactive quantity may, when propelled by sufficient gas pressure, be propelled in plug flow and each discharge line being in communication with a mold; introducing into each of the first and second gas reservoirs a predetermined volume of a gas at predetermined gas pressures sufficient to propel each quantity of material as turbulently flowing plug into the mold.

Method for small scale forming of hardenable materials of organic origin

A disposable flow cell for use in a thermal pulse flow meter of the type that incorporates a pulse heated thermal probe and a detecting thermal probe. The disposable cell has two side ports covered with a stretchable film barrier. The thermal probes extend into the flow cell through the ports stretching the barrier ahead of them so that the probes can transmit and then detect thermal pulses to a fluid flowing through the flow cell while at the same time maintaining isolation between the probes and the fluid. The invention is also a thermal pulse flow meter incorporating the above cell.

Thermal pulse flow meter with disposable cell

An improved technique and apparatus for the independent measurement of anions and cations in solution, wherein the sample ions are chromatographically displaced in a plurality of ion exchange columns by an eluting ion which is or is made light-absorbing and wherein the sample ions are detectable from decrements in absorbance of the eluting ions as revealed by photometric monitoring; and the sample ions, cations and anions, are further detected independently by means for monitoring eluting anion and cation absorbance differences calibrated according to characteristic absorbance ratios of the selected eluting ion species at a plurality of wavelengths.

Independent analysis of anions and cations using indirect photometric

Apparatus for accurately metering liquid flow based on the injection of a brief heat pulse into the flowing stream, e.g., via a miniature thermistor, and detection of an electronic time derivative of temperature downstream with, e.g., a second microprobe thermistor. This detection triggers a subsequent heat pulse and the cycle repeats, with pulse total corresponding to elapsed liquid throughput, and pulse frequency to flow rate.

Apparatus and method for metering sub-10 cc/minute liquid flow

Apparatus for accurately metering liquid flow based on the injection of a brief heat pulse into the flowing stream, e.g., via a miniature thermistor, and detection of an electronic time derivative of temperature downstream with, e.g., a second microprobe thermistor. This detection triggers a subsequent heat pulse and the cycle repeats, wth pulse total corresponding to elapsed liquid throughput, and pulse frequency to flow rate.

Growing community of inventors

Midland, MI, United States of America

Theodore E Miller, Jr