Other

Johnson & Johnson Pharmaceutical Research & Development, LLC

Theodore E Carver, Jr

James M Rinker

Tianbao Lu

Maxwell David Cummings

Francis Raymond Salemme

Michael W Pantoliano

Daniel J Parks

Karen L Milkiewicz

Raul R Calvo

Alexander J Kim

Bruce L Grasberger

Louis V LaFrance

The present invention provides a method for functionally classifying a protein that is capable of unfolding due to a thermal change. The method comprises screening one or more of a multiplicity of different molecules for their ability to shift the thermal unfolding curve of the protein, wherein a shift in the thermal unfolding curve indicates that the molecule binds to the protein or affects the stability in a measurable way; generating an activity spectrum for the protein wherein the activity spectrum reflects a set of molecules, from the multiplicity of molecules, that shift the thermal unfolding curve, of the protein and therefore are ligands that bind to the protein, comparing the activity spectrum for the protein to one or more functional reference spectrum lists; and classifying the protein according to the set of molecules in the multiplicity of different molecules that shift the thermal unfolding curve of the protein.

High throughput method for functionally classifying proteins identified using a genomics approach

The present invention is directed to a compound of Formula I: wherein A, R, and Rare defined herein. The present invention is also directed to compositions comprising compounds of Formula I, methods of using compounds of Formula I, and methods of making compounds of Formula I.

Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes

The present invention is directed to novel 1,4-benzodiazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein:

Substituted 1,4-benzodiazepines and uses thereof

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Downingtown, PA, United States of America

Theodore E Carver, Jr