Cme Telemetrix Inc.

Nir Diagnostics Inc.

Theodore E Cadell

James Samsoondar

Romuald Pawluczyk

Thomas Scecina

Ashwani Kaushal

Bronislaw Bednarz

Romauld Pawluczyk

Paul Drennan

John Kuta

Kevin Rabalais

Donald B MacHattie

Geng Lu

The present invention provides a method of calibrating a spectroscopic device for providing a non-invasive measurement of an analyte level in a sample. The method comprises the steps of: (a) providing a plurality of calibration algorithms; (b) taking a set of non-invasive measurements on said sample with said spectroscopic device; (c) calculating a predicted set of analyte levels for each of the calibration algorithms in response to the set of non-invasive measurements, each of the predicted sets of analyte levels being characterized by a variability range, a slope, an R2(a square of the correlation between said set of non-invasive measurements and said predicted set of analyte levels), and a standard error of prediction; and (d) selecting an appropriate calibration algorithm by using a suitability score based on the variability range, the slope, the Ran the standard error of prediction for each of the predicted sets of analyte levels. A method of generating suitable calibration algorithms in step (a) is also provided.

Method of calibrating a spectroscopic device

The present invention provides a thermally stable reference member comprising, at least one radiation attenuating element and at least one radiation scattering element. The radiation attenuating element comprising at least one aperture for transmission of radiation therethrough. The attenuating and scattering elements placed in series so that radiation transmitted through the reference member passes through each of the attenuating and scattering elements. The attenuating and scattering elements of the reference member may further comprise a thermally stable mount to hold the elements in a selected position relative to each other, and in relation to an instrument, or the elements may be bonded together. The radiation attenuating element may be comprised of a material selected from the group consisting of I, tungsten, brass, and a material substantially non-transparent for incident radiation, and the radiation scattering element may be comprised of a radiation scattering material selected from the group consisting of opalescent glass, S, PTFE, Z, fused silica, quartz, sapphire, diamond, and a transparent material with essentially low thermal expansion.

Electromagnetic radiation attenuating and scattering member with improved thermal stability

Described is a method for measuring the concentration of a blood constituent within a body part ( ) of a living subject which comprises irradiating a body part of the subject with a continuum of a broad spectrum of radiation in adjacent and near infrared range of the electomagnetic spectrum; collecting the band of radiation after the radiation has been directed onto the part; dispersing the continuum of collected radiation into a dispersed spectrum of component wavelengths onto a detector ( ) the detector taking measurements of at least one of transmitted or reflected radiation from the collected radiation; and transferring the measurements to a processor ( ), and then measuring the same kind of absorbance or reflectance with respect to one or more a discrete wavelengths of radiation from the longer near infrared range and using the measurements to calculate the concentration of the constituent.

Method for determination of analytes using NIR, adjacent visible spectrum and discrete NIR wavelenths

Described is a method which uses spectral data simultaneously collected in a continuous array of discrete wavelength points of the visible spectrum adjacent to the infrared and near infrared part of the light spectrum. The spectral data is collected using a number of detectors with different sensitivity ranges. Some detectors may be sensitive to visible and possibly, to part of the near infrared portion of radiation. Spectral data from die infrared spectrum is collected with the infrared detectors, and are in some embodiments insensitive to the visible links.

Method for determination of analytes using near infrared, adjacent visible spectrum and an array of longer near infrared wavelengths

The present invention provides a method of calibrating the wavelength of a target instrument, based on a calibration model developed for a primary instrument. The method comprises: (a) obtaining a reference set of at least two wavelength calibration parameters for the primary instrument; (b) obtaining a target set of at least two corresponding wavelength calibration parameters for the target instrument; (c) measuring a reference spectral response of a sample with the primary instrument; (d) measuring a target spectral response of the sample with the target instrument; (e) iteratively adjusting the target set of wavelength calibration parameters; (f) for each target set of wavelength calibration parameters, determining spectral residuals corresponding to that target set; and (g) selecting an optimum set of wavelength calibration parameters based on the spectral residuals for each target set of wavelength calibration parameters.

Method of optimizing wavelength calibration

The present invention provides an artificial member ( ) which mimics the absorbance spectrum of a body part and includes the spectral components of blood analytes. The artificial member comprises a light scattering and reflecting material, and has a chamber portion comprising one or more chambers ( ). The artificial member is configured to be reproducibly received in a measuring receptor which receptor is operatively connected to a non-invasive monitoring device.

Device for verifying the accuracy of a spectral analyzer

The present invention relates to a method of building instrument variation tolerance into calibration algorithms for spectroscopic devices for chemical composition analysis with spectroscopic methods. The method of the present invention is particularly suitable for blood glucose, cholesterol and other chemical components prediction based on near-infrared spectrophotometry measurements. A method includes developing a calibration algorithm on a first instrument; applying the calibration algorithm to a second instrument; calibrating the second instrument and adjusting the calibration algorithm to account for differences between the first instrument and the second instrument; and repeating the step of applying (above) in respect of (n) further instruments to provide a calibration algorithm which may then be used on other instruments. Methods are also provided that develop calibration algorithms by adding instrument variations, based on mathematical manipulation, of the spectral data collected on calibration instruments.

Method for creating spectral instrument variation tolerance in calibration algorithms

A method and apparatus for use in respect of samples which are assessed for quality prior to testing in a clinical analyzer. The method and apparatus identify parameters such as gel level and height of fluid above the gel in blood samples, where appropriate, for the purposes of positioning the specimen for determination of interferents. Such interferents include hemoglobin (Hb), total bilirubin and lipids. These interferents are determined by measurement of absorption of different wavelengths of light in serum or plasma, or other speciments, which are then compared with values obtained through calibration using reference measurements for the respective interferents in serum or plasma or other type of specimen. Determination of temperature of the specimen, as well as specimen type, for example whether the specimen is urine or plasma or serum, may also be carried out.

Apparatus for measuring hematocrit

A method and apparatus for use in respect of samples which are assessed for quality prior to testing in a clinical analyzer. The method and apparatus identify parameters such as gel level and height of fluid above the gel in blood samples, where appropriate, for the purposes of positioning the specimen for determination of interferents. Such interferents include hemoglobin (Hb), total bilirubin and lipids. These interferents are determined by measurement of absorption of different wavelengths of light in serum or plasma, or other specimens, which are then compared with values obtained through calibration using reference measurements for the respective interferents in serum or plasma or other type of specimen. Determinations of temperature of the specimen, as well as specimen type, for example whether the specimen is urine or plasma or serum, may also be carried out.

Apparatus and method for rapid spectrophotometric pre-test screen of specimen for a blood analyzer

A finger receptor is used with a non-invasive monitoring device to determine non-invasively the concentration of known constituents in blood or tissue. The receptor has a channel for receiving a finger of a user. The channel has a light entrance and a light exit so that light can be passed from a light source through a finger located in the channel in a direction generally normal to the finger. Extraneous light is excluded and the finger is held in position by a spring-mounted roller. The receptor has sensing means to determine when a finger has been properly positioned in the channel. Previous devices are not capable of achieving repeatable results to a sufficient degree to replace invasive methods of testing.

Finger receptor

A medical radio telemetry system has a plurality of telemeters with one telemeter being located on each patient. Each telemeter is connected to the patient to collect data such as temperature, heart rate, pacer rate, respiration rate, brain activity level and blood pressure level. Each telemeter has a patient locator system that functions in conjunction with one or more room locator transmitters. The room locator transmitters are spaced in the rooms or area where the location of a patient is being monitored. A signal from the patient locator transmitter is passed to the patient telemeter. All signals received by the patient telemeter are transmitted to an antenna system that is connected to a receiver. Preferably, there is more than one antenna system with means for switching between the systems to obtain the best signal. Each telemeter has up to six channels so that six separate signals can be sent to the receiver simultaneously. The receiver is connected to a display means for the signals.

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Conestogo, Canada

Theodore E Cadell