Orthovita, Inc.

Vita Special Purpose Corporation

Theodore D Clineff

Charanpreet S Bagga

Erik M Erbe

Gina M Nagvajara

Antony Koblish

Michael W Paris

Marissa M Darmoc

James Philip Murphy

Matthew B Havener

Marissa M Conrad

Zachary S Szczerbinski

Stephen G Gilbert

Maarten Persenaire

Lauren S Brown

Dean A Entrekin

Steven B Brown

James P Murphy

Disclosed is directed to a method for restoring bone in an animal comprising: accessing a site to be restored; loading a syringe body with a flowable bone graft material; mating the syringe body with a delivery tube; positioning the delivery tube at the site to be restored; using a syringe piston to advance the said material into the delivery tube; using the syringe piston or a plunger that mates with the delivery tube after removal of the syringe body to deliver the bone graft to the site at a force of less than 50 lbs. extrusion force; wherein said material is at least 75% porous with a mineral to polymer ratio of 80:20.

Method for restoring bone using shapeable bone graft substitute and instruments for delivery thereof

The present invention generally relates to bioactive composites of polymer and glass and, more particularly, to bioactive implants. The present invention also relates to methods of manufacturing bioactive composites. The bioactive composite finds utility in a variety of load-bearing clinical applications including spine, orthopaedic and dental procedures.

Bioactive composites of polymer and glass and method for making same

Injectable bone graft material having a biocompatible, resorbable polymer and a biocompatible, resorbable inorganic material exhibiting macro, meso, and microporosities.

Shapeable bone graft substitute and instruments for delivery thereof

The present invention relates to a method of preparing a bioactive composite, the method comprising the steps of a) adding in a solid state a biocompatible polymer and a bioactive glass to an extruder to form an extrudable material; b) applying energy to the extrudable material to at least the melting temperature of the biocompatible polymer to melt mix the biocompatible polymer and bioactive glass; and c) extruding a bioactive composite.

A syringe configured to deliver viscous compositions is described, in which the syringe may include an elongate chamber having side port(s) extending therefrom. Various viscous compositions may be inserted through the side port(s) and into the elongate chamber, which may further house a plunger for ejecting the composition. One portion of the plunger may interact with a restricted opening on the chamber to inhibit removal of the plunger from the chamber; and another portion of the plunger may have a locking structure, which cooperates with a locking structure on the chamber to selectively fix the plunger with respect to the chamber. The plunger may also be fully slidable within the chamber when the locking structures of the plunger and the elongate chamber are not engaged. Related methods of using the aforementioned syringe, as well as kits including further instruments that interact with the syringe, are also disclosed.

Syringe for the delivery of viscous compositions

The present invention generally relates to bioactive antibacterial materials and composites that enhance bone growth while preventing surgical site infection. The present invention also relates to bioactive antibacterial materials and composites that include a bimodal bioactive glass particle size distribution. The bioactive antibacterial composite finds utility in a variety of clinical applications including spine and orthopaedic procedures.

Bioactive antibacterial bone graft materials

A method for reducing the occurrence of new post-operative fractures in vertebrae of a patient's spine after a vertebroplasty procedure performed to stabilize a fracture in a vertebra of a patient comprising the steps of performing a vertebroplasty procedure to stabilize a fracture in a vertebra of the patient, wherein the vertebroplasty procedure comprises the step of injecting a material into the fractured vertebra, wherein the material is formed by mixing together a first paste and a second paste, wherein the first paste comprises at least one of a polymerizable monomer and a filler, and wherein the second paste comprises at least one of a polymerizable monomer and a filler.

Method for stabilizing vertebral body architecture

The invention relates to biocompatible bone graft materials for repairing bone defects and the application of such bone grafts. The devices of the invention comprise resorbable calcium phosphate, resorbable collagen and bioactive glasses.

Bioactive bone graft substitute

The invention relates to biocompatible bone graft materials for repairing bone defects and the application of such bone grafts. The devices of the invention comprise resorbable calcium phosphate, resorbable collagen, and bioactive glasses.

Biocompatible bone graft material having a biocompatible, resorbable polymer and a biocompatible, resorbable inorganic material exhibiting macro, meso, and microporosities.

Bone restorative carrier mediums

A pliable bone restorative having an osteoconductive foam that at least partially surrounds a biocompatible mesh and the foam comprises a biocompatible, resorbable polymer and calcium phosphate.

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Phoenixville, PA, United States of America

Theodore D Clineff