Louisiana State University and Agricultural & Mechanical College

Other

Aphios Corporation

Arphios Corporation

Theodore A Tyler

Trevor Percival Castor

Jonathan Steven Alexander

Geoffrey Purdum

J David Rios

Lisa M Schrott

Maria I Vizcaino

Richard Joseph Student

Embodiments of the present invention are directed to the oral administration of Bryostatins for the treatment of neuro-degenerative disease.

Drug delivery system and method for the treatment of neuro-degenerative disease

St. John's Wort products which have enhanced bioactivity in a serotonin re-uptake assay and enhanced stability are identified and manufactured from,biomass with supercritical and near critical fluids with and without polar cosolvents. These fluids are used to fractionate the biomass materials in several sequential steps. In each step, the biomass is subjected to a multiplicity of supercritical or near critical fluid extraction steps, with different solvation conditions used for each fraction. Thus, fractionation of the biomass is effected and the St. John's Wort products are manufactured. In addition to excellent overall yield, the bioactivity and stability of the St. John's Wort products manufactured from,biomass with supercritical and near critical fluids with and without polar cosolvents are significantly higher than that obtained by conventional organic phase extraction.

Methods for making Hypericum fractions and St. John's Wort products

Growing community of inventors

Framingham, MA, United States of America

Theodore A Tyler