Akzo Nobel N.v.

Akco Nobel

Theodora Antonia Maria Lambregts Vd Hurk

Pieter De Haan

Jocominus Antonius Maria Zwinkels

Ryoichi Morita

Adrianus Cornelis Petrus Rovers

A stabilized pharmaceutical dosage unit comprising tibolone, in an amount of from 0.1% to 10% by weight of the dosage unit, and a pharmaceutically acceptable carrier. The dosage unit is contained in a humid atmosphere of 50 to 70% relative humidity until administration.

Stabilized tibolone compositions

The invention pertains to a pharmaceutical dosage unit, such as a tablet or a capsule, comprising an effective amount of tibolone (generally of from 0.1 to 10% by weight) and a starch-containing pharmaceutically acceptable carrier (also denoted as basic granulate), wherein the carrier contains of from 10 to 100% by weight of the starch. Thus a more stable tibolone formulation is obtained, allowing dry storage and lower doses of active ingredient.

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Veghel, Netherlands

Theodora Antonia Maria Lambregts Vd Hurk