Epigenomics Ag

Theo De Vos

Joe Lograsso

Fabian Model

Volker Liebenberg

Cathy Lofton-day

Jennifer Maas

Andrew Sledziewski

Matthias Ballhause

Kurt Berlin

Matthias Schuster

Dimo Dietrich

Reimo Tetzner

Ralf Lesche

Catherine E Lofton-Day

Andrew Z Sledziewski

Sabine Maier

Susan Cottrell

Peter Adorjan

Matthias Burger

Cathy Lofton-Day

Aspects of the present invention relate to compositions and methods for providing DNA fragments from a remote sample. In particular aspects a remote sample comprising DNA is provided, DNA is isolated from the remote sample, and the isolated DNA is treated in a way which allows differentiation of methylated and unmethylated cytosine. Additional, particular embodiments provide compositions and methods for methylation analysis of DNA derived from a remote sample. Other aspects provide for compositions and methods of whole genome amplification of bisulfite treated DNA. Other aspects provide methods for determining the presence or absence of methylation of at least one cytosine, or a series of cytosines in cis, in human DNA of a blood sample, a plasma sample, a serum sample or a urine sample from a human individual.

Method for determining the presence or absence of methylation in a sample

The invention provides methods and nucleic acids for detecting, differentiating or distinguishing between colon cell proliferative disorders as well as therapy thereof by analysis of the gene EYA4 and its promoter and regulatory sequences. The invention further provides novel nucleic acid sequences useful for the cell proliferative disorder specific analysis of said gene as well as methods, assays and kits thereof.

Method and nucleic acids for the analysis of colorectal cell proliferative disorders

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Seattle, WA, United States of America

Theo De Vos