Bracco Research, USA

Bracco International Bv

Bristol-myers Squibb Compnay

E. R. Squibb Sons, Inc.

Thangavel Arunachalam

Michael F Tweedle

Ramachandran S Ranganathan

Kondareddiar Ramalingam

Adrian D Nunn

Karen E Linder

Paul W Wedeking

Natarajan Raju

Ruth Wager

Kenneth J Natalie, Jr

Rama S Ranganathan

Ruth E Wager

Ramachandran Ranganathan

Nataranjan Raju

Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the &#x3b1;, &#x3b3;, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.

Metal complexes derivatized with folate for use in diagnostic and therapeutic applications

Compounds having formulae I, II or/III, or pharmaceutically acceptable salts thereof,

N,N-dimethyldiatrizoic acid and its conjugates as hepatobiliary agents for x-ray CT imaging

Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the &agr;, &ggr;, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.

Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the .alpha., .gamma., or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.

Metal complexes derivatized with folate for use in diagnostic and

Compounds having formulae I, II or III, or pharmaceutically acceptable salts thereof, ##STR1## wherein ##STR2## R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are the same or different and are hydrogen, alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, haloalkyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl or carboxamido alkyl with the proviso that in formula I R.sub.2 and R.sub.3 cannot be methyl; and

N,N-dimethyldiatrizoic acid and its conjugates as hepatobiliary agents

The present process involves ring opening and ring closure of compounds containing a tetrahydrofuroyl ##STR1## to provide facile synthesis of compounds containing a piperidin-2-one group of the formula ##STR2##

Process for preparation of 2-oxo-1-piperidinyl derivatives

The process involves ring opening and ring closure of compounds containing a tetrahydrofuroyl group ##STR1## to provide facile synthesis of compounds containing a piperidin-2-one group of the formula ##STR2##

Process for preparation of 2-oxo-1 piperidinyl derivatives

Novel nonionic contrast agents of the formula ##STR1## or dimers of the formula ##STR2## are disclosed where X, Z and R.sub.1 -R.sub.5 are as defined herein.

Growing community of inventors

Plainsboro, NJ, United States of America

Thangavel Arunachalam