Cianna Medical, Inc.

Medtronic Corevalve LLC

Medtronic Cv Luxembourg S.a.r.l.

Other

Medtronic, Inc.

3F Therapeutics, Inc.

Medtronics Corevalve LLC

Corevalve, Inc.

Than Nguyen

Hung Nguyen

MyKim Nguyen

Stanley Komatsu

Robrecht Michiels

George D Hermann

Eduardo Chi Sing

Gail S Lebovic

Jacques Seguin

Mark A Cole

Mark Andrew Ritchart

Rodolfo C Quijano

Doug Sutton

Tommy G Nguyen

Bruno Lecointe

Stan Komatsu

Georg Boertlein

Hosheng Tu

Georg Börtlein

Jacques R Seguin

Jacques Séguin

Edward Pannek

Mark A Richart

Robert Michiels

Doug S Sutton

Mykim Nguyen

Robrecht Michielis

Luis R Urquidi

A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

Heart valve prosthesis and methods of manufacture and use

Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.

Brachytherapy apparatus and methods for using them

Heart valve prosthesis

Apparatus and methods for repairing a cardiac valve, e.g., a mitral valve, are provided. The apparatus may include an expandable frame defining a curved structure in the expanded deployed state and a membrane coupled to the expandable frame. The membrane may curve around a native leaflet, e.g., the posterior leaflet, in a first plane and curve around another leaflet, e.g., the anterior leaflet, in an orthogonal plane. The membrane may be adapted to be suspended in the flow path of the cardiac valve such a first surface of the membrane abuts the native leaflet during systole and a second surface of the membrane abuts the other native leaflet during systole, thereby reducing cardiac valve regurgitation.

Apparatus and methods for treating cardiac valve regurgitation

Implants formed by a helically wound wire and methods of using same for the treatment of a mitral heart valve. According to the invention, it has dimensions such that it is able to be screwed into the wall of the annulus and/or into the cardiac wall adjoining the annulus such that a portion of the annulus and/or of the wall is located in the perimeter of the implant; and it comprises at least one first coil able, during said screwing of the implant, to insert itself into the wall while having a first dimension and at least one second coil having a second dimension, or adopting this second dimension after implantation, the second dimension being smaller than the first dimension such that the implant, once inserted, enables contraction of the wall portion located in the perimeter of the implant.

Implant for treatment of a heart valve, in particular a mitral valve, material including such an implant, and material for insertion thereof

A cardiac valve repair device has a membrane assembly and a frame. The frame has a central structure that defines a central separation, a pair of sleeves positioned below the central structure, and a pair of atrial alignment expansion beams. Each atrial alignment expansion beam has a curved section and inner section at each opposite end that defines a scissor-crossing where they overlap each other to form a separate lower expansion clip beam at each of the opposite ends thereof. The cardiac valve repair device also includes a pair of upper expansion clip beams. A V-shaped ventricular expansion curved beam extends below the two sleeves, with the membrane assembly secured to the V-shaped ventricular expansion curved beam. A pair of ventricular alignment stabilizing beams extends downwardly from the two sleeves.

Cardiac valve repair device

Methods for delivering a prosthetic heart valve include advancing a delivery catheter containing the prosthetic heart valve to a deployment native heart valve, advancing an inner core movably coupled to a restraining sheath of the delivery catheter to expose a first end of the prosthetic heart valve, and advancing the inner core and the restraining to expose a second end of the prosthetic heart valve. The delivery catheter can include a distal flange located at a distal end of an outer core of the catheter body, configured to restrict distal longitudinal displacement of the prosthetic heart valve, and a retaining structure located proximally from the distal flange along the outer core of the catheter body, configured to restrict proximal longitudinal displacement of the prosthetic heart valve.

Methods for delivering a self-expanding valve

This implant () is formed by a helically wound wire (). According to the invention, it has dimensions such that it is able to be screwed into the wall of the annulus () and/or into the cardiac wall () adjoining this annulus () such that a portion of said annulus () and/or of said wall () is located in the perimeter of the implant (); and it comprises at least one first coil able, during said screwing of the implant (), to insert itself into said wall while having a first dimension and at least one second coil having a second dimension, or adopting this second dimension after implantation, said second dimension being smaller than the first dimension such that the implant (), once inserted, enables contraction of said wall portion located in the perimeter of this implant ().

Growing community of inventors

Fountain Valley, CA, United States of America

Than Nguyen