Medimmune Limited

Thais Cailleau

Philip Wilson Howard

Luke Masterson

Nazzareno Dimasi

Arnaud Charles Tiberghien

Niall Dickinson

William Goundry

Jason White

A compound of formula IV: as well as drug-linkers and conjugates comprising this compound, and the use of the conjugates in treating cancer.

Azetidobenzodiazepine dimers and conjugates comprising them for use in the treatment of cancer

A conjugate comprising the following topoisomerase inhibitor derivative (A*): with a linker for connecting to a Ligand Unit, wherein the linker is attached in a cleavable manner to the amino residue. The Ligand Unit is preferably an antibody. Also provided is A* with the linking unit attached, and intermediates for their synthesis, as well as the released warhead.

Compounds and conjugates thereof

A conjugate of formula (I): L-(D), wherein L is a Ligand unit, D is a Drug Linker unit of formula (II), wherein p is an integer of from 1 to 20. 

Pyrrolobenzodiazepine conjugates and their use for the treatment of cancer

A compound which is selected from A: and salts and solvates thereof. 

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Cambridge, United Kingdom

Thais Cailleau