Wake Forest University

Other

Thaddeus Wadas

Narges Tafreshi

Robert J Gillies

David L Morse

Mark Ronald McLaughlin

Hyun Joo Kil

Mark Mclaughlin

Nikunj B Bhatt

David Morse

Robert Gillies

Darpan N Pandya

RADIOTHERAPEUTIC AND COMPANION IMAGING AGENTS TO TARGET MC1R

The subject matter disclosed herein relates generally to cancer therapy and to anti-cancer compounds and imaging agents. More specifically, the subject matter disclosed herein relates to agents that target MC1R and their use in the treatment of cancer. Methods of screening for MC1R targeted agents are also disclosed.

Radiotherapeutic and companion imaging agents to target MC1R

Disclosed are novel compounds, complexes, compositions and methods using Zirconium-89 combined with azamacrocyclic chelators in connection with PET. The compositions and methods should provide better diagnostic, prognostic and therapeutic oncology treatments relative to the presently available chelator compositions due to a variety of superior properties of the disclosed compositions. The present invention also relates to a superior method of making these compounds, complexes, compositions that allows one to make compounds/complexes (and thus, compositions) that were previously unattainable.

Compounds, compositions and associated methods using zirconium-89 in immuno-positron emission tomography

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Winston-Salem, NC, United States of America

Thaddeus Wadas