Arcus Biosciences, Inc.

Tezcan Guney

Jaroslaw Kalisiak

Anh Thu Tran

Jay Patrick Powers

Manmohan Reddy Leleti

Brandon Reid Rosen

Debashis Mandal

Erick Allen Lindsey

Joel Worley Beatty

Yongli Su

Steven Donald Jacob

Xuelei Yan

Kenneth Victor Lawson

Jenna Leigh Jeffrey

Samuel Lawrie Drew

Guillaume Mata

Balint Gal

Artur Karenovich Mailyan

Zhang Wang

Kai Yu

Matthew Epplin

Clayton Hardman

Jeremy Thomas Andre Fournier

Hyunyoung Moon

Karl T Haelsig

Eric Newcomb

Corinne Nicole Foley

Rebecca Louise Grange

Eric Thomas Newcomb

Compounds that are inhibitors of at least one of ARG1 and ARG2, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by ARG1 and ARG2 are also described herein.

Inhibitors of ARG1 and/or ARG2

Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.

Tetralin and tetrahydroquinoline compounds as inhibitors of HIF-2alpha

Compounds that are inhibitors of at least one of the ARG1 and ARG2, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by ARG1 and ARG2 are also described herein.

Arginase inhibitors

Compounds that inhibit HIF-2&#x3b1;, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2&#x3b1;.

Tetralin and tetrahydroquinoline compounds as inhibitors of HIF-2&#x3b1;

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Hayward, CA, United States of America

Tezcan Guney