Koninklijke Philips Corporation N.v.

Teunis Johannes Vink

Mareike K Klee

Josephus Arnoldus Henricus Maria Kahlman

Cornelis Pieter Janse

Albertus Cornelis Den Brinker

Achim Gerhard Rolf Koerber

Jeroen Herman Lammers

Neil Francis Joye

Franciscus Hendrikus Van Heesch

Denny Mathew

Johannes Weda

Manuela Lunz

Andrew David Mitchell

Leendert Van Der Tempel

Lenneke Van Genugten

Gabriele Spina

Kevin Paul Warmerdam

Sander Kruitwagen

Edwin Van Rutten

Frank Bies

Hans Willem Van Kesteren

Alberto Fazzi

Jakob Van De Laar

Alexander Cornelis Geerlings

Tamara Mathea Elisabeth Nijsen

Hugo Hubertus Knobel

Yuanyue Wang

Lieuwe Durk Jacobus Bos

Tamara Mathea Elisabeth Nujsen

Juliana Pauline Kelly

Dirk Erneset Von Hollen

Dirk Ernest Von Hollen

Rainer Hilbig

David Paul Walker

Rene Martinus Marina Derkx

Mareike Klee

A method for synchronizing data for gas samples with volatile organic compounds. The data includes chromatographic data indicative of molecule retention times. The method includes identifying or selecting marker molecules and clustering the plurality of gas samples into a plurality of clusters according to a clustering criterion. Next, a first correction of retention time deviations is performed on the data for the gas samples between clusters by using the marker molecules as anchor points to provide a coarse reduction of retention time deviations between the data. Finally, a second correction of retention time deviations is performed on the data, so as to further reduce retention time deviations between the data. The method reduces significant retention time deviations to allow, e.g., breath sample fingerprints obtained by different equipment at different times to be compared in one database for use on a digital platform.

Alignment of breath sample data for database comparisons

Various improvements are provided to breathing training, monitoring and/or assistance devices. A portable device is provided which optionally includes a gas canister, a feedback system for implementing pressure control, and a visual output for indicating adherence to a breathing exercise to the user. The pressure control may provide regulation of different pressures for inhalation and exhalation.

Breathing training, monitoring and/or assistance device

Airway impedance of a subject using a respiratory treatment device can be measured, in accordance with one or more embodiments. A conduit is configured to communicate a flow of inhaled gas and a flow of exhaled gas to and from an airway of the subject using the respiratory treatment device. A first valve is disposed within the conduit and configured to affect the flow of exhaled gas. One or more sensors are disposed within the conduit and are configured to provide a signal conveying information associated with one or more characteristics of gas exhaled by the subject while the flow of exhaled gas is affected or unaffected by the first valve. An airway impedance monitoring module can be executed by a processor to determine an impedance metric of the airway of the subject based on the information conveyed by the signal provided by the one or more sensors.

Airway impedance measurement integrated with respiratory treatment devices

The invention is directed to a system and method for providing an ARDS indication of a patient comprising a sampling device for obtaining a gas sample of the exhaled breath of a patient, a measuring unit for measuring a content of n-octane in the exhaled breath of a patient, a controller which is able to distinguish if the patient has or may develop ARDS based on the content of n-octane in the exhaled breath of a patient resulting in a ARDS indication of the patient and provided with a protocol for providing output regarding the ARDS indication of the patient, and a user interface for indicating the ARDS indication to a user.

Method of detecting ARDS and systems for detecting ARDS

There is provided a method of determining at least one parameter value relating to nitric oxide, NO, production in the lower respiratory tract of a subject, the method comprising obtaining a plurality of measurements of NO levels in exhaled air and air flow rate during multiple exhalations of a subject performing tidal breathing; analyzing the plurality of measurements to identify exhalations where the NO produced in the lower respiratory tract dominates the NO contribution from other sources; determining at least one parameter value relating to NO in the lower respiratory tract of the subject from the measurements of NO levels and/or air flow rate obtained during the identified exhalations.

Nitric oxide measurement method and apparatus

There is provided an apparatus for monitoring the respiration of a subject, the apparatus comprising a sensor for measuring the concentration of a specified gas in air exhaled by the subject and a processor configured to provide an output indicating the concentration of the specified gas in a selected portion of the exhaled air, the selected portion of the exhaled air corresponding to air from a specific part of the respiratory system of the subject.

Method and apparatus for measuring the concentration of a gas in exhaled air

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Valkenswaard, Netherlands

Teunis Johannes Vink