National Institute for Materials Science

National Institute of Advanced Industrial Science and Technology

Japan Science and Technology Agency

Tetsuya Tateishi

Junzo Tanaka

Masanori Kikuchi

Toshimasa Uemura

Kenichi Shinomiya

Shinichi Sotome

Soichiro Itoh

Guoping Chen

A porous scaffold having pores for seeding cells characterized in that, in the outer peripheral face of the porous main body having the pores for seeding cells, a porous membrane having pores smaller than the cells is located. Thus, it is possible to provide a porous scaffold whereby the cells can be seeded at a high efficiency while preventing cell leakage and, moreover, even cells having little adhesiveness can be adhered.

Porous scaffold, method of producing the same and method of using the porous scaffold

This invention provides novel composite biomaterials having excellent bioadaptability and bone inductivity and a process for producing the same. The composite biomaterials comprise hydroxyapatite, collagen, and alginate and have microporous structures in which the c-axis of the hydroxyapatite is oriented along the collagen fibers.

Composite biomaterials

This invention relates to a process for producing porous and composite materials comprising steps of: freezing a complex containing at least one calcium salt selected from calcium carbonate, calcium phosphate, and hydroxyapatite and collagen, at least a part of which is gelatinized; and then lyophilizing the resultant. The porous and composite materials obtained by the method of the present invention have large pore diameters, high porosities, and adequate mechanical strengths and biodegradability. Thus, they are suitable for implants such as bone fillers, drug carriers for sustained-release, and the like.

Process for producing porous composite materials

Growing community of inventors

Ibaraki, Japan

Tetsuya Tateishi